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Conversion of Helix 1 into a Loop in Prion Protein Misfolding
[Image: see text] Cellular prion protein PrP(C) consists of three α-helices, one β-sheet, and an unstructured N-terminal domain. Misfolding of this protein into the scrapie form (PrP(Sc)) increases dramatically the β-sheet content. H1 is the most stable helix on PrP(C) and contains an unusual number...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948551/ https://www.ncbi.nlm.nih.gov/pubmed/36844589 http://dx.doi.org/10.1021/acsomega.3c00212 |