Disrupting the ArcA Regulatory Network Amplifies the Fitness Cost of Tetracycline Resistance in Escherichia coli

There is an urgent need for strategies to discover secondary drugs to prevent or disrupt antimicrobial resistance (AMR), which is causing >700,000 deaths annually. Here, we demonstrate that tetracycline-resistant (Tet(R)) Escherichia coli undergoes global transcriptional and metabolic remodeling,...

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Detalles Bibliográficos
Autores principales: Arrieta-Ortiz, Mario L., Pan, Min, Kaur, Amardeep, Pepper-Tunick, Evan, Srinivas, Vivek, Dash, Ananya, Immanuel, Selva Rupa Christinal, Brooks, Aaron N., Shepherd, Tyson R., Baliga, Nitin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948699/
https://www.ncbi.nlm.nih.gov/pubmed/36537814
http://dx.doi.org/10.1128/msystems.00904-22

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