CRISPR-Cas-Guided Mutagenesis of Chromosome and Virulence Plasmid in Shigella flexneri by Cytosine Base Editing

Shigella is a Gram-negative bacterium that invades the human gut epithelium. The resulting infection, shigellosis, is the deadliest bacterial diarrheal disease. Much of the information about the genes dictating the pathophysiology of Shigella, both on the chromosome and the virulence plasmid, was ob...

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Detalles Bibliográficos
Autores principales: Sharma, Atin, Omer Aden, Ruqiya, Puhar, Andrea, Cisneros, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948704/
https://www.ncbi.nlm.nih.gov/pubmed/36541764
http://dx.doi.org/10.1128/msystems.01045-22

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