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Rhino Orbital Cerebral Mucormycosis in Covid-19 Crisis

Rhino-Orbital cerebral Mucormycosis (ROCM) an angioinvasive fungal infection commonly seen in diabetic and immunocompromised patients. In recent days, due to COVID 19 pandemic mucormycosis has been significantly increased (Smith et al. in Radiol Cardiothorac Imaging 2(5):e200280, 2020). In this stud...

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Autores principales: Vadivel, Suresh, Gowrishankar, M., Vetrivel, Kanagavel, Sujatha, B., Navaneethan, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948777/
https://www.ncbi.nlm.nih.gov/pubmed/36855632
http://dx.doi.org/10.1007/s12070-023-03474-1
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author Vadivel, Suresh
Gowrishankar, M.
Vetrivel, Kanagavel
Sujatha, B.
Navaneethan, P.
author_facet Vadivel, Suresh
Gowrishankar, M.
Vetrivel, Kanagavel
Sujatha, B.
Navaneethan, P.
author_sort Vadivel, Suresh
collection PubMed
description Rhino-Orbital cerebral Mucormycosis (ROCM) an angioinvasive fungal infection commonly seen in diabetic and immunocompromised patients. In recent days, due to COVID 19 pandemic mucormycosis has been significantly increased (Smith et al. in Radiol Cardiothorac Imaging 2(5):e200280, 2020). In this study we evaluate the involvement, clinical features, contributing risk factors and outcome of post covid Rhino orbital cerebral mucormycosis. A cross sectional descriptive study was conducted on post covid rhino orbital cerebral mucormycosis patients from May 2021 to October 2021 in Otorhinolaryngology department of Stanley Medical college Chennai. We collected detailed history of Covid-19 hospital stay, treatment taken, co morbidities, Endoscopic findings, management and outcome. 243 cases analysed with median age 51 years (range 28–75 years) and male predominance with M:F ratio 1.6. The median time interval between covid and ROCM was 20 (15–35) days. Based on involvement 111 (46%) Stage-II, 87 (36%) Stage-I, 37 (15%) stage III and 8 (3%) stage IV disease observed. with overall mortality of 5.7%. Among which 230 (94.6%) patients had diabetes mellitus, 111 (45.8%) patients received steroid and 134 (54.3%) had immunomodulators during covid management. Despite of surgical debridement and antifungal therapy 14 (5.8%) patients died from mucormycosis. we conclude that covid be the predisposing factor for mucormycosis especially in patients with diabetes and increased usage of steroids. Treatment needs multimodality approach with antifungals and surgical debridement with surveillance fir good outcome.
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spelling pubmed-99487772023-02-24 Rhino Orbital Cerebral Mucormycosis in Covid-19 Crisis Vadivel, Suresh Gowrishankar, M. Vetrivel, Kanagavel Sujatha, B. Navaneethan, P. Indian J Otolaryngol Head Neck Surg Original Article Rhino-Orbital cerebral Mucormycosis (ROCM) an angioinvasive fungal infection commonly seen in diabetic and immunocompromised patients. In recent days, due to COVID 19 pandemic mucormycosis has been significantly increased (Smith et al. in Radiol Cardiothorac Imaging 2(5):e200280, 2020). In this study we evaluate the involvement, clinical features, contributing risk factors and outcome of post covid Rhino orbital cerebral mucormycosis. A cross sectional descriptive study was conducted on post covid rhino orbital cerebral mucormycosis patients from May 2021 to October 2021 in Otorhinolaryngology department of Stanley Medical college Chennai. We collected detailed history of Covid-19 hospital stay, treatment taken, co morbidities, Endoscopic findings, management and outcome. 243 cases analysed with median age 51 years (range 28–75 years) and male predominance with M:F ratio 1.6. The median time interval between covid and ROCM was 20 (15–35) days. Based on involvement 111 (46%) Stage-II, 87 (36%) Stage-I, 37 (15%) stage III and 8 (3%) stage IV disease observed. with overall mortality of 5.7%. Among which 230 (94.6%) patients had diabetes mellitus, 111 (45.8%) patients received steroid and 134 (54.3%) had immunomodulators during covid management. Despite of surgical debridement and antifungal therapy 14 (5.8%) patients died from mucormycosis. we conclude that covid be the predisposing factor for mucormycosis especially in patients with diabetes and increased usage of steroids. Treatment needs multimodality approach with antifungals and surgical debridement with surveillance fir good outcome. Springer India 2023-02-23 2023-04 /pmc/articles/PMC9948777/ /pubmed/36855632 http://dx.doi.org/10.1007/s12070-023-03474-1 Text en © Association of Otolaryngologists of India 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
spellingShingle Original Article
Vadivel, Suresh
Gowrishankar, M.
Vetrivel, Kanagavel
Sujatha, B.
Navaneethan, P.
Rhino Orbital Cerebral Mucormycosis in Covid-19 Crisis
title Rhino Orbital Cerebral Mucormycosis in Covid-19 Crisis
title_full Rhino Orbital Cerebral Mucormycosis in Covid-19 Crisis
title_fullStr Rhino Orbital Cerebral Mucormycosis in Covid-19 Crisis
title_full_unstemmed Rhino Orbital Cerebral Mucormycosis in Covid-19 Crisis
title_short Rhino Orbital Cerebral Mucormycosis in Covid-19 Crisis
title_sort rhino orbital cerebral mucormycosis in covid-19 crisis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948777/
https://www.ncbi.nlm.nih.gov/pubmed/36855632
http://dx.doi.org/10.1007/s12070-023-03474-1
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