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Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil
BACKGROUND: Ohio's age-adjusted opioid overdose fatality rate is double the national average. In an ever-evolving epidemic, it is crucial to monitor trends to inform public health interventions. METHODS: A retrospective study was conducted using the Medical Examiner's decedent case files f...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948855/ https://www.ncbi.nlm.nih.gov/pubmed/36846577 http://dx.doi.org/10.1016/j.dadr.2022.100069 |
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author | Bhullar, Manreet K. Gilson, Thomas P. Singer, Mendel E. |
author_facet | Bhullar, Manreet K. Gilson, Thomas P. Singer, Mendel E. |
author_sort | Bhullar, Manreet K. |
collection | PubMed |
description | BACKGROUND: Ohio's age-adjusted opioid overdose fatality rate is double the national average. In an ever-evolving epidemic, it is crucial to monitor trends to inform public health interventions. METHODS: A retrospective study was conducted using the Medical Examiner's decedent case files for all accidental opioid-related adult overdose deaths in Cuyahoga County (Cleveland), Ohio in 2017. Characterization of trends was based on autopsy/toxicology and first responder reports, medical records and death scene investigations. RESULTS: Of 543 accidental opioid-related adult overdose fatalities, 64.1% died from 3+ drugs. The most common cause of death (COD) drugs included fentanyl (63.4%), heroin (44.4%), cocaine (37.0%) and carfentanil (35.0%). There were four times as many African American decedents as two years prior. Three or more COD drugs was >50% more common in those with fentanyl (Prevalence Ratio (PR) = 1.56[1.34–1.70]; p<.001) or carfentanil (PR = 1.51[1.33–1.70]; p<.001) as a COD drug, more common with a history of prescription drug abuse (PR = 1.16[1.02–1.33]; p=.025), but less common in divorced/widowed decedents (PR = 0.83[0.71–0.97]; p=.022). Carfentanil was nearly 4 times as prevalent in those with previous illicit drug use (PR = 3.88[1.09–13.70]; p=.025), and less common in those with previous medical history (PR = 0.72[0.55–0.94]; p=.016) or age 50+ (PR = 0.72[0.53–0.97]; p=.031). CONCLUSIONS: Accidental opioid-related overdose fatalities in Cuyahoga County adults were dominated by 3+ COD drugs, with cocaine/fentanyl mixtures driving sharp increases in African American fatalities. Carfentanil was more prevalent in people fitting the profile of recreational drug use. This data can inform harm reduction interventions. |
format | Online Article Text |
id | pubmed-9948855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99488552023-02-23 Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil Bhullar, Manreet K. Gilson, Thomas P. Singer, Mendel E. Drug Alcohol Depend Rep Full Length Report BACKGROUND: Ohio's age-adjusted opioid overdose fatality rate is double the national average. In an ever-evolving epidemic, it is crucial to monitor trends to inform public health interventions. METHODS: A retrospective study was conducted using the Medical Examiner's decedent case files for all accidental opioid-related adult overdose deaths in Cuyahoga County (Cleveland), Ohio in 2017. Characterization of trends was based on autopsy/toxicology and first responder reports, medical records and death scene investigations. RESULTS: Of 543 accidental opioid-related adult overdose fatalities, 64.1% died from 3+ drugs. The most common cause of death (COD) drugs included fentanyl (63.4%), heroin (44.4%), cocaine (37.0%) and carfentanil (35.0%). There were four times as many African American decedents as two years prior. Three or more COD drugs was >50% more common in those with fentanyl (Prevalence Ratio (PR) = 1.56[1.34–1.70]; p<.001) or carfentanil (PR = 1.51[1.33–1.70]; p<.001) as a COD drug, more common with a history of prescription drug abuse (PR = 1.16[1.02–1.33]; p=.025), but less common in divorced/widowed decedents (PR = 0.83[0.71–0.97]; p=.022). Carfentanil was nearly 4 times as prevalent in those with previous illicit drug use (PR = 3.88[1.09–13.70]; p=.025), and less common in those with previous medical history (PR = 0.72[0.55–0.94]; p=.016) or age 50+ (PR = 0.72[0.53–0.97]; p=.031). CONCLUSIONS: Accidental opioid-related overdose fatalities in Cuyahoga County adults were dominated by 3+ COD drugs, with cocaine/fentanyl mixtures driving sharp increases in African American fatalities. Carfentanil was more prevalent in people fitting the profile of recreational drug use. This data can inform harm reduction interventions. Elsevier 2022-06-15 /pmc/articles/PMC9948855/ /pubmed/36846577 http://dx.doi.org/10.1016/j.dadr.2022.100069 Text en © 2022 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Full Length Report Bhullar, Manreet K. Gilson, Thomas P. Singer, Mendel E. Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil |
title | Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil |
title_full | Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil |
title_fullStr | Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil |
title_full_unstemmed | Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil |
title_short | Trends in opioid overdose fatalities in Cuyahoga County, Ohio: Multi-drug mixtures, the African-American community and carfentanil |
title_sort | trends in opioid overdose fatalities in cuyahoga county, ohio: multi-drug mixtures, the african-american community and carfentanil |
topic | Full Length Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948855/ https://www.ncbi.nlm.nih.gov/pubmed/36846577 http://dx.doi.org/10.1016/j.dadr.2022.100069 |
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