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Physiological reprogramming in vivo mediated by Sox4 pioneer factor activity

Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated has not been investigated in animals. In cell culture, pioneer transcription factors mediate “reprogramming” by opening new chromatin sites for...

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Detalles Bibliográficos
Autores principales: Katsuda, Takeshi, Sussman, Jonathan, Ito, Kenji, Katznelson, Andrew, Yuan, Salina, Li, Jinyang, Merrell, Allyson J., Takenaka, Naomi, Cure, Hector, Li, Qinglan, Rasool, Reyaz Ur, Asangani, Irfan A., Zaret, Kenneth S., Stanger, Ben Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948957/
https://www.ncbi.nlm.nih.gov/pubmed/36824858
http://dx.doi.org/10.1101/2023.02.14.528556

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