Joint Modeling of Gene-Environment Correlations and Interactions using Polygenic Risk Scores in Case-Control Studies

Polygenic risk scores (PRS) are rapidly emerging as aggregated measures of disease-risk associated with many genetic variants. Understanding the interplay of PRS with environmental factors is critical for interpreting and applying PRS in a wide variety of settings. We develop an efficient method for...

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Detalles Bibliográficos
Autores principales: Wang, Ziqiao, Shi, Wen, Carroll, Raymond J., Chatterjee, Nilanjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948994/
https://www.ncbi.nlm.nih.gov/pubmed/36824704
http://dx.doi.org/10.1101/2023.02.14.528572

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