The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR(+) CD8(+) effector state and its deletion improves checkpoint blockade

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T cell exhaustion (T(EX)) impairs the ability of T cells to clear chronic infection or cancer. While exhausted T cells are hypofunctional, some exhausted T cells retain effector gene signatures, a feature that is associated with expression of KLRs (killer lectin-like receptors). Although KLR(+) T ce...

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Detalles Bibliográficos
Autores principales: McClory, Susan E., Bardhan, Oishi, Rome, Kelly S., Giles, Josephine R., Baxter, Amy E., Xu, Lanwei, Gimotty, Phyllis A., Faryabi, Robert B., Wherry, E. John, Pear, Warren S., Jordan, Martha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948998/
https://www.ncbi.nlm.nih.gov/pubmed/36824931
http://dx.doi.org/10.1101/2023.02.16.528833
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