Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver Disease

Hepatic stellate cells (HSC) are non-parenchymal liver cells that produce extracellular matrix comprising fibrotic lesions in chronic liver diseases. Prior work demonstrated that mitochondrial pyruvate carrier (MPC) inhibitors suppress HSC activation and fibrosis in a mouse model of metabolic dysfun...

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Detalles Bibliográficos
Autores principales: Habibi, Mohammad, Ferguson, Daniel, Eichler, Sophie J., Chan, Mandy M., LaPoint, Andrew, Shew, Trevor M., He, Mai, Lutkewitte, Andrew J., Schilling, Joel D., Cho, Kevin Y., Patti, Gary J., Finck, Brian N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949033/
https://www.ncbi.nlm.nih.gov/pubmed/36824926
http://dx.doi.org/10.1101/2023.02.13.528384

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