CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated immune evasion

The mechanisms underlying immune evasion and immunotherapy resistance in small cell lung cancer (SCLC) remain unclear. Herein, we investigate the role of CRACD tumor suppressor in SCLC. We found that CRACD is frequently inactivated in SCLC, and Cracd knockout (KO) significantly accelerates SCLC deve...

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Detalles Bibliográficos
Autores principales: Zhang, Shengzhe, Kim, Kee-Beom, Huang, Yuanjian, Kim, Dong-Wook, Kim, Bongjun, Ko, Kyung-Pil, Zou, Gengyi, Zhang, Jie, Jun, Sohee, Kirk, Nicole A., Hwang, Ye Eun, Ban, Young Ho, Chan, Joseph M., Rudin, Charles M., Park, Kwon-Sik, Park, Jae-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949038/
https://www.ncbi.nlm.nih.gov/pubmed/36824957
http://dx.doi.org/10.1101/2023.02.15.528365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949038/
https://www.ncbi.nlm.nih.gov/pubmed/36824957
http://dx.doi.org/10.1101/2023.02.15.528365

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