Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

Nucleotide changes in gene regulatory elements are important determinants of neuronal development and disease. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogated the cis-regulatory activity of 102,767 sequences, including...

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Detalles Bibliográficos
Autores principales: Deng, Chengyu, Whalen, Sean, Steyert, Marilyn, Ziffra, Ryan, Przytycki, Pawel F., Inoue, Fumitaka, Pereira, Daniela A., Capauto, Davide, Norton, Scott, Vaccarino, Flora M., Pollen, Alex, Nowakowski, Tomasz J., Ahituv, Nadav, Pollard, Katherine S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949039/
https://www.ncbi.nlm.nih.gov/pubmed/36824845
http://dx.doi.org/10.1101/2023.02.15.528663

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