Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

DNA hydroxymethylation (5hmC) is the most abundant oxidative derivative of DNA methylation (5mC) and is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been implicated in many age-related diseases, the function...

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Detalles Bibliográficos
Autores principales: Occean, James R., Yang, Na, Sun, Yan, Dawkins, Marshall S., Munk, Rachel, Belair, Cedric, Dar, Showkat, Anerillas, Carlos, Wang, Lin, Shi, Changyou, Dunn, Christopher, Bernier, Michel, Price, Nathan L., Kim, Julie S., Cui, Chang-Yi, Fan, Jinshui, Bhattacharyya, Moitrayee, De, Supriyo, Maragkakis, Manolis, deCabo, Rafael, Sidoli, Simone, Sen, Payel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949049/
https://www.ncbi.nlm.nih.gov/pubmed/36824863
http://dx.doi.org/10.1101/2023.02.15.528714

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