Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics(1–3). Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinica...

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Detalles Bibliográficos
Autores principales: Li, Yen-Der, Ma, Michelle W., Hassan, Muhammad Murtaza, Hunkeler, Moritz, Teng, Mingxing, Puvar, Kedar, Lumpkin, Ryan, Sandoval, Brittany, Jin, Cyrus Y., Ficarro, Scott B., Wang, Michelle Y., Xu, Shawn, Groendyke, Brian J., Sigua, Logan H., Tavares, Isidoro, Zou, Charles, Tsai, Jonathan M., Park, Paul M. C., Yoon, Hojong, Majewski, Felix C., Marto, Jarrod A., Qi, Jun, Nowak, Radosław P., Donovan, Katherine A., Słabicki, Mikołaj, Gray, Nathanael S., Fischer, Eric S., Ebert, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949066/
https://www.ncbi.nlm.nih.gov/pubmed/36824856
http://dx.doi.org/10.1101/2023.02.14.528208

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