Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows

Macrocyclic peptides are attractive for chemoproteomic applications due to their modular synthesis and potential for high target selectivity. We describe a solid phase synthesis method for the efficient generation of libraries of small macrocycles that contain an electrophile and alkyne handle. The...

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Detalles Bibliográficos
Autores principales: Faucher, Franco F., Abegg, Daniel, Ipock, Phillip, Adibekian, Alexander, Lovell, Scott, Bogyo, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949109/
https://www.ncbi.nlm.nih.gov/pubmed/36824748
http://dx.doi.org/10.1101/2023.02.17.529022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949109/
https://www.ncbi.nlm.nih.gov/pubmed/36824748
http://dx.doi.org/10.1101/2023.02.17.529022

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