Cargando…

Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows

Macrocyclic peptides are attractive for chemoproteomic applications due to their modular synthesis and potential for high target selectivity. We describe a solid phase synthesis method for the efficient generation of libraries of small macrocycles that contain an electrophile and alkyne handle. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faucher, Franco F., Abegg, Daniel, Ipock, Phillip, Adibekian, Alexander, Lovell, Scott, Bogyo, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949109/ https://www.ncbi.nlm.nih.gov/pubmed/36824748 http://dx.doi.org/10.1101/2023.02.17.529022

Ejemplares similares

Aryl fluorosulfates: powerful and versatile partners in cross-coupling reactions
por: Saraswat, Shelesh Krishna, et al.
Publicado: (2023)

Solid Phase versus Solution Phase Synthesis of Heterocyclic Macrocycles
por: Kim, Seong Jong, et al.
Publicado: (2013)

Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead
por: Nowak, Radosław P., et al.
Publicado: (2023)

Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase
por: Bolding, Julie E., et al.
Publicado: (2022)

Chemoproteomic profiling of itaconations in Salmonella
por: Zhang, Yanling, et al.
Publicado: (2021)

Perfluoro Allyl Fluorosulfate (FAFS): A Versatile Building Block for New Fluoroallylic Compounds
por: Wlassics, Ivan, et al.
Publicado: (2011)

Recent Advances in Macrocyclic Drugs and Microwave-Assisted and/or Solid-Supported Synthesis of Macrocycles
por: Sun, Dianqing
Publicado: (2022)

Fluorosulfate-containing pyrazole heterocycles as selective BuChE inhibitors: structure-activity relationship and biological evaluation for the treatment of Alzheimer’s disease
por: Li, Huan-Huan, et al.
Publicado: (2022)

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
por: Hewings, David S., et al.
Publicado: (2018)

A chemoproteomic portrait of the oncometabolite fumarate
por: Kulkarni, Rhushikesh A., et al.
Publicado: (2019)

Recent Advances in the Synthesis and Applications of Nitrogen-Containing Macrocycles
por: Grajewski, Jakub
Publicado: (2022)

Chemoproteomic Profiling of Bile Acid Interacting Proteins
por: Zhuang, Shentian, et al.
Publicado: (2017)

Chemoproteomic discovery of a human RNA ligase
por: Yuan, Yizhi, et al.
Publicado: (2023)

Divergent synthesis and identification of the cellular targets of deoxyelephantopins
por: Lagoutte, Roman, et al.
Publicado: (2016)

Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction
por: Wu, Yue, et al.
Publicado: (2021)

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics
por: Pinto-Fernández, Adán, et al.
Publicado: (2019)

Cysteine Pseudoprolines for Thiol Protection and Peptide Macrocyclization Enhancement in Fmoc-Based Solid-Phase Peptide Synthesis
por: Postma, Tobias M., et al.
Publicado: (2014)

Chemoproteomic profiling of host and pathogen enzymes active in cholera
por: Hatzios, Stavroula K., et al.
Publicado: (2016)

Chemoproteomics reveals Toll-like receptor fatty acylation
por: Chesarino, Nicholas M, et al.
Publicado: (2014)

Chemoproteomic profiling and discovery of protein electrophiles in human cells
por: Matthews, Megan L, et al.
Publicado: (2016)

Determining the Effect of Pterostilbene on Insulin Secretion Using Chemoproteomics
por: Cassiano, Chiara, et al.
Publicado: (2020)

Chemoproteomic capture of RNA binding activity in living cells
por: Heindel, Andrew J., et al.
Publicado: (2023)

A macrocyclic oligofuran: synthesis, solid state structure and electronic properties
por: Mulay, Sandip V., et al.
Publicado: (2019)

Protease Activated Probes for Real-Time Ratiometric Imaging of Solid Tumors
por: Faucher, Franco F., et al.
Publicado: (2023)

Insights on the Synthesis of N-Heterocycles Containing Macrocycles and Their Complexion and Biological Properties
por: Malek, Fouad, et al.
Publicado: (2022)

Chemoproteomic profiling reveals cellular targets of nitro-fatty acids
por: Fang, Ming-Yu, et al.
Publicado: (2021)

Chemoproteomic mapping of human milk oligosaccharide (HMO) interactions in cells
por: Hassan, Abdullah A., et al.
Publicado: (2022)

Synthesis of Flavonol-Bearing Probes for Chemoproteomic and Bioinformatic Analyses of Asteraceae Petals in Search of Novel Flavonoid Enzymes
por: Kempf, Karl, et al.
Publicado: (2023)

Macrocycle as a “Container” for Dinitramide Salts
por: Il’yasov, Sergey G., et al.
Publicado: (2022)

Synthesis and macrocyclization-induced emission enhancement of benzothiadiazole-based macrocycle
por: Li, Shuo, et al.
Publicado: (2022)

Site‐Selective, Modular Diversification of Polyhalogenated Aryl Fluorosulfates (ArOSO(2)F) Enabled by an Air‐Stable Pd(I) Dimer
por: Mendel, Marvin, et al.
Publicado: (2019)

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics
por: Ghidelli-Disse, Sonja, et al.
Publicado: (2014)

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles
por: Wang, Chu, et al.
Publicado: (2013)

Chemoproteomic Profiling of Lysine Acetyltransferases Highlights an Expanded Landscape of Catalytic Acetylation
por: Montgomery, David C., et al.
Publicado: (2014)

A chemoproteomic method for identifying cellular targets of covalent kinase inhibitors
por: Chen, Ying-Chu, et al.
Publicado: (2016)

Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe
por: Chen, Ying, et al.
Publicado: (2017)

Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity
por: Parasar, Bibudha, et al.
Publicado: (2019)

Unbiased Identification of the Liposome Protein Corona using Photoaffinity-based Chemoproteomics
por: Pattipeiluhu, Roy, et al.
Publicado: (2020)

A Paal–Knorr agent for chemoproteomic profiling of targets of isoketals in cells
por: Wang, Min-Ran, et al.
Publicado: (2021)

Comprehensive Structure–Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C–H Oxidations
por: Amatuni, Alexander, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2qtoqaoivl6ehclf88g93du2m3