Prediction and Design of Protease Enzyme Specificity Using a Structure-Aware Graph Convolutional Network

Site-specific proteolysis by the enzymatic cleavage of small linear sequence motifs is a key post-translational modification involved in physiology and disease. The ability to robustly and rapidly predict protease substrate specificity would also enable targeted proteolytic cleavage – editing – of a...

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Detalles Bibliográficos
Autores principales: Lu, Changpeng, Lubin, Joseph H., Sarma, Vidur V., Stentz, Samuel Z., Wang, Guanyang, Wang, Sijian, Khare, Sagar D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949123/
https://www.ncbi.nlm.nih.gov/pubmed/36824945
http://dx.doi.org/10.1101/2023.02.16.528728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949123/
https://www.ncbi.nlm.nih.gov/pubmed/36824945
http://dx.doi.org/10.1101/2023.02.16.528728

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