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Prediction and Design of Protease Enzyme Specificity Using a Structure-Aware Graph Convolutional Network
Site-specific proteolysis by the enzymatic cleavage of small linear sequence motifs is a key post-translational modification involved in physiology and disease. The ability to robustly and rapidly predict protease substrate specificity would also enable targeted proteolytic cleavage – editing – of a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949123/ https://www.ncbi.nlm.nih.gov/pubmed/36824945 http://dx.doi.org/10.1101/2023.02.16.528728 |