Cargando…

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice

The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via de novo lipogenesis (DNL) when carbohydrates are abundant. Mitochondrial pyruvate metabolism is thought to play important roles in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yiew, Nicole K.H., Deja, Stanislaw, Ferguson, Daniel, Cho, Kevin, Jarasvaraparn, Chaowapong, Jacome-Sosa, Miriam, Lutkewitte, Andrew J., Mukherjee, Sandip, Fu, Xiaorong, Singer, Jason M., Patti, Gary J., Burgess, Shawn C., Finck, Brian N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949129/ https://www.ncbi.nlm.nih.gov/pubmed/36824879 http://dx.doi.org/10.1101/2023.02.17.528992

Ejemplares similares

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
por: Yiew, Nicole K.H., et al.
Publicado: (2023)

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism
por: Ferguson, Daniel, et al.
Publicado: (2023)

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids
por: Martino, Michael R., et al.
Publicado: (2022)

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids
por: Martino, Michael R., et al.
Publicado: (2022)

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice
por: Hodges, Wesley T., et al.
Publicado: (2021)

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization
por: Onodera, Toshiharu, et al.
Publicado: (2023)

Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver
por: Fu, Xiaorong, et al.
Publicado: (2023)

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice
por: Martino, Michael R., et al.
Publicado: (2023)

Correlation of Gastroesophageal reflux disease Assessment Symptom Questionnaire to impedance-pH measurements in children
por: Prachuapthunyachart, Sittichoke, et al.
Publicado: (2017)

Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway
por: Jhuang, Hong-Jhih, et al.
Publicado: (2015)

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
por: Kovářová, Julie, et al.
Publicado: (2018)

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
por: Kumashiro, Naoki, et al.
Publicado: (2013)

Glucose Transporter 8 (GLUT8) Mediates Fructose-induced de Novo Lipogenesis and Macrosteatosis
por: DeBosch, Brian J., et al.
Publicado: (2014)

Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis
por: Zhou, Feiye, et al.
Publicado: (2020)

Association of autoimmune hepatitis type 1 in a child with Evans syndrome
por: Jarasvaraparn, Chaowapong, et al.
Publicado: (2017)

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
por: Chen, Jingjing, et al.
Publicado: (2018)

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis
por: LaMoia, Traci E., et al.
Publicado: (2022)

Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes
por: Nishi, Kiyoto, et al.
Publicado: (2023)

De Novo Lipogenesis Products and Endogenous Lipokines
por: Yilmaz, Mustafa, et al.
Publicado: (2016)

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice
por: Fang, Zhipeng, et al.
Publicado: (2023)

mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes
por: Khan, Rukshar, et al.
Publicado: (2023)

A Sweet New Role for Ubiquitin-Specific Protease 2 in Controlling Hepatic Gluconeogenesis
por: Finck, Brian N.
Publicado: (2012)

Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis
por: Harding, Scott V, et al.
Publicado: (2015)

Proteomic Examination for Gluconeogenesis Pathway-Shift during Polyhydroxyalkanoate Formation in Cupriavidus necator Grown on Glycerol
por: Tanadchangsaeng, Nuttapol, et al.
Publicado: (2020)

Clostridium difficile colitis complicating Kawasaki disease in children: Two case reports
por: Rojas Gallegos, Maria Belen, et al.
Publicado: (2018)

Validation of the Antidiabetic and Hypolipidemic Effects of Hawthorn by Assessment of Gluconeogenesis and Lipogenesis Related Genes and AMP-Activated Protein Kinase Phosphorylation
por: Shih, Chun-Ching, et al.
Publicado: (2013)

Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver Disease
por: Habibi, Mohammad, et al.
Publicado: (2023)

Expanding Roles of De Novo Lipogenesis in Breast Cancer
por: Simeone, Pasquale, et al.
Publicado: (2021)

DAXX drives de novo lipogenesis and contributes to tumorigenesis
por: Mahmud, Iqbal, et al.
Publicado: (2023)

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
por: Yiew, Nicole K.H., et al.
Publicado: (2023)

Insulin Controls Triacylglycerol Synthesis through Control of Glycerol Metabolism and Despite Increased Lipogenesis
por: Ho-Palma, Ana Cecilia, et al.
Publicado: (2019)

Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity
por: Lutkewitte, Andrew J., et al.
Publicado: (2020)

Description of the First Case of Adenomyomatosis of the Gallbladder in an Infant
por: Zarate, Yuri A., et al.
Publicado: (2014)

The Characteristics of Esophageal Multichannel Intraluminal Impedance-PH Measurements in Infants Experiencing Brief Resolved Unexplained Events
por: Jarasvaraparn, Chaowapong, et al.
Publicado: (2018)

Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting
por: Wang, Yujue, et al.
Publicado: (2019)

Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis
por: Katayama, Yuko, et al.
Publicado: (2022)

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-(13)C]Pyruvate as Markers of Renal Gluconeogenesis
por: Yoshihara, Hikari A. I., et al.
Publicado: (2021)

Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis
por: Pizzato, Hannah A., et al.
Publicado: (2023)

The Relationship between Sleep Disturbance, Quality of Life and Psychosocial Functioning in Pediatric Patients with Inflammatory Bowel Disease
por: Jarasvaraparn, Chaowapong, et al.
Publicado: (2018)

Direct Visualization of De novo Lipogenesis in Single Living Cells
por: Li, Junjie, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_80nbnescch2rd6o8b785u7k8j5