Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis

Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-specific signaling network rewiring, continue to challenge therapeutic efficacy. By leverag...

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Detalles Bibliográficos
Autores principales: Rosenberger, George, Li, Wenxue, Turunen, Mikko, He, Jing, Subramaniam, Prem S, Pampou, Sergey, Griffin, Aaron T, Karan, Charles, Kerwin, Patrick, Murray, Diana, Honig, Barry, Liu, Yansheng, Califano, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949144/
https://www.ncbi.nlm.nih.gov/pubmed/36824919
http://dx.doi.org/10.1101/2023.02.15.528736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949144/
https://www.ncbi.nlm.nih.gov/pubmed/36824919
http://dx.doi.org/10.1101/2023.02.15.528736

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