Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A

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The normally antiviral enzyme APOBEC3A(1-4) is an endogenous mutagen in many different human cancers(5-7), where it becomes hijacked to fuel tumor evolvability. APOBEC3A’s single-stranded DNA C-to-U editing activity(1,8) results in multiple mutagenic outcomes including signature single-base substitu...

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Detalles Bibliográficos
Autores principales: Harjes, Stefan, Kurup, Harikrishnan M., Rieffer, Amanda E., Bayaijargal, Maitsetseg, Filitcheva, Jana, Su, Yongdong, Hale, Tracy K., Filichev, Vyacheslav V., Harjes, Elena, Harris, Reuben S., Jameson, Geoffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949147/
https://www.ncbi.nlm.nih.gov/pubmed/36824964
http://dx.doi.org/10.1101/2023.02.17.528918
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