Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing

Mutations accumulate in the genome of every cell of the body throughout life, causing cancer and other genetic diseases(1–4). Almost all of these mosaic mutations begin as nucleotide mismatches or damage in only one of the two strands of the DNA prior to becoming double-strand mutations if unrepaire...

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Detalles Bibliográficos
Autores principales: Liu, Mei Hong, Costa, Benjamin, Choi, Una, Bandler, Rachel C., Lassen, Emilie, Grońska-Pęski, Marta, Schwing, Adam, Murphy, Zachary R., Rosenkjær, Daniel, Picciotto, Shany, Bianchi, Vanessa, Stengs, Lucie, Edwards, Melissa, Loh, Caitlin A., Truong, Tina K., Brand, Randall E., Pastinen, Tomi, Wagner, J. Richard, Skytte, Anne-Bine, Tabori, Uri, Shoag, Jonathan E., Evrony, Gilad D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949150/
https://www.ncbi.nlm.nih.gov/pubmed/36824744
http://dx.doi.org/10.1101/2023.02.19.526140

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