Chronic morphine induces adaptations in opioid receptor signaling in a thalamo-cortico-striatal circuit that are projection-dependent, sex-specific and regulated by mu opioid receptor phosphorylation

Chronic opioid exposure induces tolerance to the pain-relieving effects of opioids but sensitization to some other effects. While the occurrence of these adaptations is well-understood, the underlying cellular mechanisms are less clear. This study aimed to determine how chronic treatment with morphi...

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Detalles Bibliográficos
Autores principales: Jaeckel, Elizabeth R., Arias-Hervert, Erwin R., Perez-Medina, Alberto L., Herrera, Yoani N., Schulz, Stefan, Birdsong, William T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949156/
https://www.ncbi.nlm.nih.gov/pubmed/36824766
http://dx.doi.org/10.1101/2023.02.13.528057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949156/
https://www.ncbi.nlm.nih.gov/pubmed/36824766
http://dx.doi.org/10.1101/2023.02.13.528057

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