The association between childhood adversity and the conserved transcriptional response to adversity (CTRA) in sexual minority men

Adverse childhood experiences (ACES) increase risk for mental and physical health disorders in adulthood, particularly in individuals from sexual and ethnic minority groups. The effects of ACES on health may be mediated by the immune system. The exact mechanisms by which an environmental exposure, such as childhood adversity, can affect the immune system are still unknown. The aim of this study was to determine whether early adversity predicts significant changes in the expression of a predefined set of immune–related genes, known as the conserved transcriptional response to adversity (CTRA), in a diverse group of sexual minority men (SMM). Participants included HIV positive and negative males from the mSTUDY. Expression data from 53 CTRA genes were obtained at baseline and 12-month follow-up. Childhood adversity was measured with the 10-item ACES questionnaire. Wilcoxon rank sum and chi-squared tests were used to assess differences in sociodemographic variables and HIV status between exposed (cumulative ACES ≥ 3) and unexposed groups (cumulative ACES ≤ 2). Linear mixed models were used to determine associations between ACES (cumulative score, dichotomous measure and subscales) and CTRA gene expression. There were no differences in age and employment status between the exposed and unexposed groups. A larger number of exposed participants were HIV positive than in the unexposed group (p = 0.03). There were no significant associations between any of the ACES variables and CTRA gene expression. A range of factors may have contributed to this unexpected finding. Further studies are needed to assess the biological effects of ACES in adulthood.