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Methods for Mediation Analysis with High-Dimensional DNA Methylation Data: Possible Choices and Comparison

Epigenetic researchers often evaluate DNA methylation as a mediator between social/environmental exposures and disease, but modern statistical methods for jointly evaluating many mediators have not been widely adopted. We compare seven methods for high-dimensional mediation analysis with continuous...

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Detalles Bibliográficos
Autores principales:	Clark-Boucher, Dylan, Zhou, Xiang, Du, Jiacong, Liu, Yongmei, Needham, Belinda L, Smith, Jennifer A, Mukherjee, Bhramar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949196/ https://www.ncbi.nlm.nih.gov/pubmed/36824903 http://dx.doi.org/10.1101/2023.02.10.23285764

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