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NLRP3 agonist enhances radiation-induced immune priming and promotes abscopal responses in anti-PD1 resistant model
Radiotherapy (XRT), a well-known activator of the inflammasome and immune priming, is in part capable of reversing resistance to anti-PD1 treatment. Although NLRP3 is typically observed for its role in exacerbating XRT-induced tissue damage, the NLRP3 inflammasome can also be protective and augment...
Autores principales: | Barsoumian, Hampartsoum B., He, Kewen, Hsu, Ethan, Bertolet, Genevieve, Sezen, Duygu, Hu, Yun, Cortez, Maria Angelica, Welsh, James W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949246/ https://www.ncbi.nlm.nih.gov/pubmed/36824846 http://dx.doi.org/10.21203/rs.3.rs-2570782/v1 |
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