NLRP3 agonist enhances radiation-induced immune priming and promotes abscopal responses in anti-PD1 resistant model

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Radiotherapy (XRT), a well-known activator of the inflammasome and immune priming, is in part capable of reversing resistance to anti-PD1 treatment. Although NLRP3 is typically observed for its role in exacerbating XRT-induced tissue damage, the NLRP3 inflammasome can also be protective and augment...

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Detalles Bibliográficos
Autores principales: Barsoumian, Hampartsoum B., He, Kewen, Hsu, Ethan, Bertolet, Genevieve, Sezen, Duygu, Hu, Yun, Cortez, Maria Angelica, Welsh, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949246/
https://www.ncbi.nlm.nih.gov/pubmed/36824846
http://dx.doi.org/10.21203/rs.3.rs-2570782/v1
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