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Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep

The worldwide sheep population comprises more than 1000 breeds. Together, these exhibit a considerable morphological diversity, which has not been extensively investigated at the molecular level. Here, we analyze whole-genome sequencing individuals of 1,098 domestic sheep from 154 breeds, and 69 wil...

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Autores principales: Cheng, Hong, Zhang, Zhuangbiao, Wen, Jiayue, Lenstra, Johannes A., Heller, Rasmus, Cai, Yudong, Guo, Yingwei, Li, Ming, Li, Ran, Li, Wenrong, He, Sangang, Wang, Jintao, Shao, Junjie, Song, Yuxuan, Zhang, Lei, Billah, Masum, Wang, Xihong, Liu, Mingjun, Jiang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949681/
https://www.ncbi.nlm.nih.gov/pubmed/36821549
http://dx.doi.org/10.1371/journal.pgen.1010615
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author Cheng, Hong
Zhang, Zhuangbiao
Wen, Jiayue
Lenstra, Johannes A.
Heller, Rasmus
Cai, Yudong
Guo, Yingwei
Li, Ming
Li, Ran
Li, Wenrong
He, Sangang
Wang, Jintao
Shao, Junjie
Song, Yuxuan
Zhang, Lei
Billah, Masum
Wang, Xihong
Liu, Mingjun
Jiang, Yu
author_facet Cheng, Hong
Zhang, Zhuangbiao
Wen, Jiayue
Lenstra, Johannes A.
Heller, Rasmus
Cai, Yudong
Guo, Yingwei
Li, Ming
Li, Ran
Li, Wenrong
He, Sangang
Wang, Jintao
Shao, Junjie
Song, Yuxuan
Zhang, Lei
Billah, Masum
Wang, Xihong
Liu, Mingjun
Jiang, Yu
author_sort Cheng, Hong
collection PubMed
description The worldwide sheep population comprises more than 1000 breeds. Together, these exhibit a considerable morphological diversity, which has not been extensively investigated at the molecular level. Here, we analyze whole-genome sequencing individuals of 1,098 domestic sheep from 154 breeds, and 69 wild sheep from seven Ovis species. On average, we detected 6.8%, 1.0% and 0.2% introgressed sequence in domestic sheep originating from Iranian mouflon, urial and argali, respectively, with rare introgressions from other wild species. Interestingly, several introgressed haplotypes contributed to the morphological differentiations across sheep breeds, such as a RXFP2 haplotype from Iranian mouflon conferring the spiral horn trait, a MSRB3 haplotype from argali strongly associated with ear morphology, and a VPS13B haplotype probably originating from urial and mouflon possibly associated with facial traits. Our results reveal that introgression events from wild Ovis species contributed to the high rate of morphological differentiation in sheep breeds, but also to individual variation within breeds. We propose that long divergent haplotypes are a ubiquitous source of phenotypic variation that allows adaptation to a variable environment, and that these remain intact in the receiving population probably due to reduced recombination.
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spelling pubmed-99496812023-02-24 Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep Cheng, Hong Zhang, Zhuangbiao Wen, Jiayue Lenstra, Johannes A. Heller, Rasmus Cai, Yudong Guo, Yingwei Li, Ming Li, Ran Li, Wenrong He, Sangang Wang, Jintao Shao, Junjie Song, Yuxuan Zhang, Lei Billah, Masum Wang, Xihong Liu, Mingjun Jiang, Yu PLoS Genet Research Article The worldwide sheep population comprises more than 1000 breeds. Together, these exhibit a considerable morphological diversity, which has not been extensively investigated at the molecular level. Here, we analyze whole-genome sequencing individuals of 1,098 domestic sheep from 154 breeds, and 69 wild sheep from seven Ovis species. On average, we detected 6.8%, 1.0% and 0.2% introgressed sequence in domestic sheep originating from Iranian mouflon, urial and argali, respectively, with rare introgressions from other wild species. Interestingly, several introgressed haplotypes contributed to the morphological differentiations across sheep breeds, such as a RXFP2 haplotype from Iranian mouflon conferring the spiral horn trait, a MSRB3 haplotype from argali strongly associated with ear morphology, and a VPS13B haplotype probably originating from urial and mouflon possibly associated with facial traits. Our results reveal that introgression events from wild Ovis species contributed to the high rate of morphological differentiation in sheep breeds, but also to individual variation within breeds. We propose that long divergent haplotypes are a ubiquitous source of phenotypic variation that allows adaptation to a variable environment, and that these remain intact in the receiving population probably due to reduced recombination. Public Library of Science 2023-02-23 /pmc/articles/PMC9949681/ /pubmed/36821549 http://dx.doi.org/10.1371/journal.pgen.1010615 Text en © 2023 Cheng et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cheng, Hong
Zhang, Zhuangbiao
Wen, Jiayue
Lenstra, Johannes A.
Heller, Rasmus
Cai, Yudong
Guo, Yingwei
Li, Ming
Li, Ran
Li, Wenrong
He, Sangang
Wang, Jintao
Shao, Junjie
Song, Yuxuan
Zhang, Lei
Billah, Masum
Wang, Xihong
Liu, Mingjun
Jiang, Yu
Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
title Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
title_full Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
title_fullStr Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
title_full_unstemmed Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
title_short Long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
title_sort long divergent haplotypes introgressed from wild sheep are associated with distinct morphological and adaptive characteristics in domestic sheep
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949681/
https://www.ncbi.nlm.nih.gov/pubmed/36821549
http://dx.doi.org/10.1371/journal.pgen.1010615
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