Cargando…

Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the nervous system and result in neurological symptoms. The most common feature of central nervous system involvement is hypoxia and congestion. This study aimed to evaluate the histopathology of cerebral tissue in deceased pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Nouri, Majid, Soleiman-Meigooni, Saeed, Mohammadi, Shadi, Sakhabakhsh, Mehdi, Yaghmayee, Ramin, Fotoohi, Mahtab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949774/
https://www.ncbi.nlm.nih.gov/pubmed/36845816
http://dx.doi.org/10.1097/MS9.0000000000000203
_version_ 1784893018541654016
author Nouri, Majid
Soleiman-Meigooni, Saeed
Mohammadi, Shadi
Sakhabakhsh, Mehdi
Yaghmayee, Ramin
Fotoohi, Mahtab
author_facet Nouri, Majid
Soleiman-Meigooni, Saeed
Mohammadi, Shadi
Sakhabakhsh, Mehdi
Yaghmayee, Ramin
Fotoohi, Mahtab
author_sort Nouri, Majid
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the nervous system and result in neurological symptoms. The most common feature of central nervous system involvement is hypoxia and congestion. This study aimed to evaluate the histopathology of cerebral tissue in deceased patients with coronavirus disease 2019 (COVID-19). METHODS: In a case series study, we took cerebral samples of 30 deceased patients with COVID-19 through supraorbital bone from January to May 2021. The samples were fixed in a formalin solution, stained with haematoxylin–eosin dyes and studied by two expert pathologists. The Ethics Committee of AJA University of Medical Sciences approved this study with code IR.AJAUMS.REC.1399.030. RESULTS: The mean age of the patients was 73.8 years, and the most common underlying disease was hypertension. Cerebral tissue samples showed hypoxic–ischaemic changes in 28 (93.3%), microhaemorrhage in six (20%), lymphocytic infiltration in five (16.7%) and thrombosis in three samples (10%). CONCLUSION: Hypoxic–ischaemic change was the most common neuropathology in our patient. Our study showed that many patients with severe COVID-19 may develop central nervous system involvement.
format Online
Article
Text
id pubmed-9949774
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-99497742023-02-24 Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran Nouri, Majid Soleiman-Meigooni, Saeed Mohammadi, Shadi Sakhabakhsh, Mehdi Yaghmayee, Ramin Fotoohi, Mahtab Ann Med Surg (Lond) Case Reports Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the nervous system and result in neurological symptoms. The most common feature of central nervous system involvement is hypoxia and congestion. This study aimed to evaluate the histopathology of cerebral tissue in deceased patients with coronavirus disease 2019 (COVID-19). METHODS: In a case series study, we took cerebral samples of 30 deceased patients with COVID-19 through supraorbital bone from January to May 2021. The samples were fixed in a formalin solution, stained with haematoxylin–eosin dyes and studied by two expert pathologists. The Ethics Committee of AJA University of Medical Sciences approved this study with code IR.AJAUMS.REC.1399.030. RESULTS: The mean age of the patients was 73.8 years, and the most common underlying disease was hypertension. Cerebral tissue samples showed hypoxic–ischaemic changes in 28 (93.3%), microhaemorrhage in six (20%), lymphocytic infiltration in five (16.7%) and thrombosis in three samples (10%). CONCLUSION: Hypoxic–ischaemic change was the most common neuropathology in our patient. Our study showed that many patients with severe COVID-19 may develop central nervous system involvement. Lippincott Williams & Wilkins 2023-02-07 /pmc/articles/PMC9949774/ /pubmed/36845816 http://dx.doi.org/10.1097/MS9.0000000000000203 Text en © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/) (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Case Reports
Nouri, Majid
Soleiman-Meigooni, Saeed
Mohammadi, Shadi
Sakhabakhsh, Mehdi
Yaghmayee, Ramin
Fotoohi, Mahtab
Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran
title Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran
title_full Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran
title_fullStr Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran
title_full_unstemmed Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran
title_short Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran
title_sort neuropathology of 30 deceased patients with covid-19: a case series in tehran, iran
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949774/
https://www.ncbi.nlm.nih.gov/pubmed/36845816
http://dx.doi.org/10.1097/MS9.0000000000000203
work_keys_str_mv AT nourimajid neuropathologyof30deceasedpatientswithcovid19acaseseriesintehraniran
AT soleimanmeigoonisaeed neuropathologyof30deceasedpatientswithcovid19acaseseriesintehraniran
AT mohammadishadi neuropathologyof30deceasedpatientswithcovid19acaseseriesintehraniran
AT sakhabakhshmehdi neuropathologyof30deceasedpatientswithcovid19acaseseriesintehraniran
AT yaghmayeeramin neuropathologyof30deceasedpatientswithcovid19acaseseriesintehraniran
AT fotoohimahtab neuropathologyof30deceasedpatientswithcovid19acaseseriesintehraniran