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Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the nervous system and result in neurological symptoms. The most common feature of central nervous system involvement is hypoxia and congestion. This study aimed to evaluate the histopathology of cerebral tissue in deceased pati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949774/ https://www.ncbi.nlm.nih.gov/pubmed/36845816 http://dx.doi.org/10.1097/MS9.0000000000000203 |
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author | Nouri, Majid Soleiman-Meigooni, Saeed Mohammadi, Shadi Sakhabakhsh, Mehdi Yaghmayee, Ramin Fotoohi, Mahtab |
author_facet | Nouri, Majid Soleiman-Meigooni, Saeed Mohammadi, Shadi Sakhabakhsh, Mehdi Yaghmayee, Ramin Fotoohi, Mahtab |
author_sort | Nouri, Majid |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the nervous system and result in neurological symptoms. The most common feature of central nervous system involvement is hypoxia and congestion. This study aimed to evaluate the histopathology of cerebral tissue in deceased patients with coronavirus disease 2019 (COVID-19). METHODS: In a case series study, we took cerebral samples of 30 deceased patients with COVID-19 through supraorbital bone from January to May 2021. The samples were fixed in a formalin solution, stained with haematoxylin–eosin dyes and studied by two expert pathologists. The Ethics Committee of AJA University of Medical Sciences approved this study with code IR.AJAUMS.REC.1399.030. RESULTS: The mean age of the patients was 73.8 years, and the most common underlying disease was hypertension. Cerebral tissue samples showed hypoxic–ischaemic changes in 28 (93.3%), microhaemorrhage in six (20%), lymphocytic infiltration in five (16.7%) and thrombosis in three samples (10%). CONCLUSION: Hypoxic–ischaemic change was the most common neuropathology in our patient. Our study showed that many patients with severe COVID-19 may develop central nervous system involvement. |
format | Online Article Text |
id | pubmed-9949774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-99497742023-02-24 Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran Nouri, Majid Soleiman-Meigooni, Saeed Mohammadi, Shadi Sakhabakhsh, Mehdi Yaghmayee, Ramin Fotoohi, Mahtab Ann Med Surg (Lond) Case Reports Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can affect the nervous system and result in neurological symptoms. The most common feature of central nervous system involvement is hypoxia and congestion. This study aimed to evaluate the histopathology of cerebral tissue in deceased patients with coronavirus disease 2019 (COVID-19). METHODS: In a case series study, we took cerebral samples of 30 deceased patients with COVID-19 through supraorbital bone from January to May 2021. The samples were fixed in a formalin solution, stained with haematoxylin–eosin dyes and studied by two expert pathologists. The Ethics Committee of AJA University of Medical Sciences approved this study with code IR.AJAUMS.REC.1399.030. RESULTS: The mean age of the patients was 73.8 years, and the most common underlying disease was hypertension. Cerebral tissue samples showed hypoxic–ischaemic changes in 28 (93.3%), microhaemorrhage in six (20%), lymphocytic infiltration in five (16.7%) and thrombosis in three samples (10%). CONCLUSION: Hypoxic–ischaemic change was the most common neuropathology in our patient. Our study showed that many patients with severe COVID-19 may develop central nervous system involvement. Lippincott Williams & Wilkins 2023-02-07 /pmc/articles/PMC9949774/ /pubmed/36845816 http://dx.doi.org/10.1097/MS9.0000000000000203 Text en © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/) (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Case Reports Nouri, Majid Soleiman-Meigooni, Saeed Mohammadi, Shadi Sakhabakhsh, Mehdi Yaghmayee, Ramin Fotoohi, Mahtab Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran |
title | Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran |
title_full | Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran |
title_fullStr | Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran |
title_full_unstemmed | Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran |
title_short | Neuropathology of 30 deceased patients with COVID-19: a case series in Tehran, Iran |
title_sort | neuropathology of 30 deceased patients with covid-19: a case series in tehran, iran |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949774/ https://www.ncbi.nlm.nih.gov/pubmed/36845816 http://dx.doi.org/10.1097/MS9.0000000000000203 |
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