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Serum vitamin D and antinuclear antibody level in oral lichen planus patients: a cross-sectional study

Vitamin D is a secosteroid prohormone that regulates the immune system. Antinuclear antibody (ANA) is a protein antibody made against substances inside the nucleus of cells. Serum vitamin D and ANA levels progress to psoriasis and oral cancer. The present study aimed to measure the serum vitamin D a...

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Autor principal: Nosratzehi, Tahereh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949789/
https://www.ncbi.nlm.nih.gov/pubmed/36845785
http://dx.doi.org/10.1097/MS9.0000000000000115
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author Nosratzehi, Tahereh
author_facet Nosratzehi, Tahereh
author_sort Nosratzehi, Tahereh
collection PubMed
description Vitamin D is a secosteroid prohormone that regulates the immune system. Antinuclear antibody (ANA) is a protein antibody made against substances inside the nucleus of cells. Serum vitamin D and ANA levels progress to psoriasis and oral cancer. The present study aimed to measure the serum vitamin D and ANA levels in patients with oral lichen planus (OLP), an autoimmune and precancerous disease. METHODS: We conducted this cross-sectional study on patients with OLP (n=50) and healthy individuals (n=50). We used the enzyme-linked immunosorbent assay method to measure serum vitamin D and ANA levels and Mann–Whitney U-test and t-test to analyze data. RESULTS: The present study showed that 14 (28%) patients with OLP had vitamin D deficiency, and 18 (36%) had insufficient vitamin D. Further, 9 (18%) and 15 (30%) of the participants in the control group suffer from vitamin D deficiency and insufficient vitamin D level, respectively. Results showed a significant relationship between levels of serum vitamin D in both groups. The level of ANA positive in patients with OLP was 6 (12%). The results of the t-test showed no significant difference between the mean serum ANA levels in the two nodes with an 80% confidence interval (P=0.34). CONCLUSION: Researchers of the present study reported low serum vitamin D in many OLP patients. Due to the prevalence of vitamin D deficiency in society, we need to perform comprehensive studies to evaluate the deficiency’s effects on pathogenesis.
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spelling pubmed-99497892023-02-24 Serum vitamin D and antinuclear antibody level in oral lichen planus patients: a cross-sectional study Nosratzehi, Tahereh Ann Med Surg (Lond) Original Research Vitamin D is a secosteroid prohormone that regulates the immune system. Antinuclear antibody (ANA) is a protein antibody made against substances inside the nucleus of cells. Serum vitamin D and ANA levels progress to psoriasis and oral cancer. The present study aimed to measure the serum vitamin D and ANA levels in patients with oral lichen planus (OLP), an autoimmune and precancerous disease. METHODS: We conducted this cross-sectional study on patients with OLP (n=50) and healthy individuals (n=50). We used the enzyme-linked immunosorbent assay method to measure serum vitamin D and ANA levels and Mann–Whitney U-test and t-test to analyze data. RESULTS: The present study showed that 14 (28%) patients with OLP had vitamin D deficiency, and 18 (36%) had insufficient vitamin D. Further, 9 (18%) and 15 (30%) of the participants in the control group suffer from vitamin D deficiency and insufficient vitamin D level, respectively. Results showed a significant relationship between levels of serum vitamin D in both groups. The level of ANA positive in patients with OLP was 6 (12%). The results of the t-test showed no significant difference between the mean serum ANA levels in the two nodes with an 80% confidence interval (P=0.34). CONCLUSION: Researchers of the present study reported low serum vitamin D in many OLP patients. Due to the prevalence of vitamin D deficiency in society, we need to perform comprehensive studies to evaluate the deficiency’s effects on pathogenesis. Lippincott Williams & Wilkins 2023-02-07 /pmc/articles/PMC9949789/ /pubmed/36845785 http://dx.doi.org/10.1097/MS9.0000000000000115 Text en © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/) License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Original Research
Nosratzehi, Tahereh
Serum vitamin D and antinuclear antibody level in oral lichen planus patients: a cross-sectional study
title Serum vitamin D and antinuclear antibody level in oral lichen planus patients: a cross-sectional study
title_full Serum vitamin D and antinuclear antibody level in oral lichen planus patients: a cross-sectional study
title_fullStr Serum vitamin D and antinuclear antibody level in oral lichen planus patients: a cross-sectional study
title_full_unstemmed Serum vitamin D and antinuclear antibody level in oral lichen planus patients: a cross-sectional study
title_short Serum vitamin D and antinuclear antibody level in oral lichen planus patients: a cross-sectional study
title_sort serum vitamin d and antinuclear antibody level in oral lichen planus patients: a cross-sectional study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949789/
https://www.ncbi.nlm.nih.gov/pubmed/36845785
http://dx.doi.org/10.1097/MS9.0000000000000115
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