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Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes

Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we use CRISPR-Cas9-edited human-induced pluripotent stem cells (hiPSCs) harboring either the mild V620I or lethal T8...

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Detalles Bibliográficos
Autores principales:	Dicks, Amanda R, Maksaev, Grigory I, Harissa, Zainab, Savadipour, Alireza, Tang, Ruhang, Steward, Nancy, Liedtke, Wolfgang, Nichols, Colin G, Wu, Chia-Lung, Guilak, Farshid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Stem Cells and Regenerative Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949800/ https://www.ncbi.nlm.nih.gov/pubmed/36810131 http://dx.doi.org/10.7554/eLife.71154

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