Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease

Apoptotic colopathy is a pattern of injury not frequently associated with Crohn's disease (CD) despite its association with medications used in CD management. We describe a patient with CD on methotrexate who underwent a diagnostic colonoscopy for abdominal pain and diarrhea, with biopsies demo...

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Detalles Bibliográficos
Autores principales: Chittajallu, Vibhu, Liu, Wendy, Nguyen, Vu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949825/
https://www.ncbi.nlm.nih.gov/pubmed/36846357
http://dx.doi.org/10.14309/crj.0000000000000980
Descripción
Sumario:Apoptotic colopathy is a pattern of injury not frequently associated with Crohn's disease (CD) despite its association with medications used in CD management. We describe a patient with CD on methotrexate who underwent a diagnostic colonoscopy for abdominal pain and diarrhea, with biopsies demonstrating apoptotic colopathy. After methotrexate discontinuation, repeat colonoscopy demonstrated resolution of apoptotic colopathy in addition to diarrhea improvement.

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