Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease

Apoptotic colopathy is a pattern of injury not frequently associated with Crohn's disease (CD) despite its association with medications used in CD management. We describe a patient with CD on methotrexate who underwent a diagnostic colonoscopy for abdominal pain and diarrhea, with biopsies demo...

Descripción completa

Detalles Bibliográficos
Autores principales: Chittajallu, Vibhu, Liu, Wendy, Nguyen, Vu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Image
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949825/
https://www.ncbi.nlm.nih.gov/pubmed/36846357
http://dx.doi.org/10.14309/crj.0000000000000980
_version_ 1784893031181189120
author Chittajallu, Vibhu
Liu, Wendy
Nguyen, Vu
author_facet Chittajallu, Vibhu
Liu, Wendy
Nguyen, Vu
author_sort Chittajallu, Vibhu
collection PubMed
description Apoptotic colopathy is a pattern of injury not frequently associated with Crohn's disease (CD) despite its association with medications used in CD management. We describe a patient with CD on methotrexate who underwent a diagnostic colonoscopy for abdominal pain and diarrhea, with biopsies demonstrating apoptotic colopathy. After methotrexate discontinuation, repeat colonoscopy demonstrated resolution of apoptotic colopathy in addition to diarrhea improvement.
format Online
Article
Text
id pubmed-9949825
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer
record_format MEDLINE/PubMed
spelling pubmed-99498252023-02-24 Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease Chittajallu, Vibhu Liu, Wendy Nguyen, Vu ACG Case Rep J Image Apoptotic colopathy is a pattern of injury not frequently associated with Crohn's disease (CD) despite its association with medications used in CD management. We describe a patient with CD on methotrexate who underwent a diagnostic colonoscopy for abdominal pain and diarrhea, with biopsies demonstrating apoptotic colopathy. After methotrexate discontinuation, repeat colonoscopy demonstrated resolution of apoptotic colopathy in addition to diarrhea improvement. Wolters Kluwer 2023-02-23 /pmc/articles/PMC9949825/ /pubmed/36846357 http://dx.doi.org/10.14309/crj.0000000000000980 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Image
Chittajallu, Vibhu
Liu, Wendy
Nguyen, Vu
Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease
title Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease
title_full Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease
title_fullStr Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease
title_full_unstemmed Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease
title_short Methotrexate-Induced Apoptotic Colopathy in Crohn's Disease
title_sort methotrexate-induced apoptotic colopathy in crohn's disease
topic Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949825/
https://www.ncbi.nlm.nih.gov/pubmed/36846357
http://dx.doi.org/10.14309/crj.0000000000000980
work_keys_str_mv AT chittajalluvibhu methotrexateinducedapoptoticcolopathyincrohnsdisease
AT liuwendy methotrexateinducedapoptoticcolopathyincrohnsdisease
AT nguyenvu methotrexateinducedapoptoticcolopathyincrohnsdisease

Ejemplares similares