Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report

BACKGROUND: Bamlanivimab and etesevimab had been granted emergency use authorization in children under 12 years who are at risk of progression from mild/moderate coronavirus disease 2019 to severe disease and hospitalization. CASE REPORT: We report on a 5-year-old white male with preexisting conditi...

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Autores principales: Pillai, Rajapillai L. I., Dziel, Caroline, Vogel, Stephanie, Szczerba, Frank, Chang, Weijen W., Camelo, Ingrid Y., Paez, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950013/
https://www.ncbi.nlm.nih.gov/pubmed/36823658
http://dx.doi.org/10.1186/s13256-023-03779-3
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author Pillai, Rajapillai L. I.
Dziel, Caroline
Vogel, Stephanie
Szczerba, Frank
Chang, Weijen W.
Camelo, Ingrid Y.
Paez, Armando
author_facet Pillai, Rajapillai L. I.
Dziel, Caroline
Vogel, Stephanie
Szczerba, Frank
Chang, Weijen W.
Camelo, Ingrid Y.
Paez, Armando
author_sort Pillai, Rajapillai L. I.
collection PubMed
description BACKGROUND: Bamlanivimab and etesevimab had been granted emergency use authorization in children under 12 years who are at risk of progression from mild/moderate coronavirus disease 2019 to severe disease and hospitalization. CASE REPORT: We report on a 5-year-old white male with preexisting conditions, predisposing him to severe disease, who developed hypoxia and flushing 3 minutes into his infusion, thus meeting the criteria for anaphylaxis. CONCLUSIONS: We believe this patient developed either an immunoglobulin E-mediated anaphylactic or a non-immunoglobulin E-mediated anaphylactoid reaction to bamlanivimab and etesevimab, which is an important possibility to consider on administration.
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spelling pubmed-99500132023-02-24 Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report Pillai, Rajapillai L. I. Dziel, Caroline Vogel, Stephanie Szczerba, Frank Chang, Weijen W. Camelo, Ingrid Y. Paez, Armando J Med Case Rep Case Report BACKGROUND: Bamlanivimab and etesevimab had been granted emergency use authorization in children under 12 years who are at risk of progression from mild/moderate coronavirus disease 2019 to severe disease and hospitalization. CASE REPORT: We report on a 5-year-old white male with preexisting conditions, predisposing him to severe disease, who developed hypoxia and flushing 3 minutes into his infusion, thus meeting the criteria for anaphylaxis. CONCLUSIONS: We believe this patient developed either an immunoglobulin E-mediated anaphylactic or a non-immunoglobulin E-mediated anaphylactoid reaction to bamlanivimab and etesevimab, which is an important possibility to consider on administration. BioMed Central 2023-02-24 /pmc/articles/PMC9950013/ /pubmed/36823658 http://dx.doi.org/10.1186/s13256-023-03779-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Pillai, Rajapillai L. I.
Dziel, Caroline
Vogel, Stephanie
Szczerba, Frank
Chang, Weijen W.
Camelo, Ingrid Y.
Paez, Armando
Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report
title Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report
title_full Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report
title_fullStr Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report
title_full_unstemmed Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report
title_short Monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report
title_sort monoclonal antibody infusion reaction with bamlanivimab and etesevimab in a 5-year-old male with coronavirus disease 2019: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950013/
https://www.ncbi.nlm.nih.gov/pubmed/36823658
http://dx.doi.org/10.1186/s13256-023-03779-3
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