Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4

Protein arginine deiminases (PAD) 4 is an enzyme that catalyzes citrullination of protein and its role in autoimmune diseases has been established through clinical genetics and gene knock out studies in mice. Further, studies with PAD4 – deficient mice have shown that PAD4 deficiency does not lead t...

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Detalles Bibliográficos
Autores principales: Gajendran, Chandru, Fukui, Shoichi, Sadhu, Naveen M., Zainuddin, Mohammed, Rajagopal, Sridharan, Gosu, Ramachandraiah, Gutch, Sarah, Fukui, Saeko, Sheehy, Casey E., Chu, Long, Vishwakarma, Santosh, Jeyaraj, D. A., Hallur, Gurulingappa, Wagner, Denisa D., Sivanandhan, Dhanalakshmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950073/
https://www.ncbi.nlm.nih.gov/pubmed/36823444
http://dx.doi.org/10.1038/s41598-023-30246-2

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