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Low-dimensional encoding of decisions in parietal cortex reflects long-term training history

Neurons in parietal cortex exhibit task-related activity during decision-making tasks. However, it remains unclear how long-term training to perform different tasks over months or even years shapes neural computations and representations. We examine lateral intraparietal area (LIP) responses during...

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Autores principales: Latimer, Kenneth W., Freedman, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950136/
https://www.ncbi.nlm.nih.gov/pubmed/36823109
http://dx.doi.org/10.1038/s41467-023-36554-5
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author Latimer, Kenneth W.
Freedman, David J.
author_facet Latimer, Kenneth W.
Freedman, David J.
author_sort Latimer, Kenneth W.
collection PubMed
description Neurons in parietal cortex exhibit task-related activity during decision-making tasks. However, it remains unclear how long-term training to perform different tasks over months or even years shapes neural computations and representations. We examine lateral intraparietal area (LIP) responses during a visual motion delayed-match-to-category task. We consider two pairs of male macaque monkeys with different training histories: one trained only on the categorization task, and another first trained to perform fine motion-direction discrimination (i.e., pretrained). We introduce a novel analytical approach—generalized multilinear models—to quantify low-dimensional, task-relevant components in population activity. During the categorization task, we found stronger cosine-like motion-direction tuning in the pretrained monkeys than in the category-only monkeys, and that the pretrained monkeys’ performance depended more heavily on fine discrimination between sample and test stimuli. These results suggest that sensory representations in LIP depend on the sequence of tasks that the animals have learned, underscoring the importance of considering training history in studies with complex behavioral tasks.
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spelling pubmed-99501362023-02-25 Low-dimensional encoding of decisions in parietal cortex reflects long-term training history Latimer, Kenneth W. Freedman, David J. Nat Commun Article Neurons in parietal cortex exhibit task-related activity during decision-making tasks. However, it remains unclear how long-term training to perform different tasks over months or even years shapes neural computations and representations. We examine lateral intraparietal area (LIP) responses during a visual motion delayed-match-to-category task. We consider two pairs of male macaque monkeys with different training histories: one trained only on the categorization task, and another first trained to perform fine motion-direction discrimination (i.e., pretrained). We introduce a novel analytical approach—generalized multilinear models—to quantify low-dimensional, task-relevant components in population activity. During the categorization task, we found stronger cosine-like motion-direction tuning in the pretrained monkeys than in the category-only monkeys, and that the pretrained monkeys’ performance depended more heavily on fine discrimination between sample and test stimuli. These results suggest that sensory representations in LIP depend on the sequence of tasks that the animals have learned, underscoring the importance of considering training history in studies with complex behavioral tasks. Nature Publishing Group UK 2023-02-23 /pmc/articles/PMC9950136/ /pubmed/36823109 http://dx.doi.org/10.1038/s41467-023-36554-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Latimer, Kenneth W.
Freedman, David J.
Low-dimensional encoding of decisions in parietal cortex reflects long-term training history
title Low-dimensional encoding of decisions in parietal cortex reflects long-term training history
title_full Low-dimensional encoding of decisions in parietal cortex reflects long-term training history
title_fullStr Low-dimensional encoding of decisions in parietal cortex reflects long-term training history
title_full_unstemmed Low-dimensional encoding of decisions in parietal cortex reflects long-term training history
title_short Low-dimensional encoding of decisions in parietal cortex reflects long-term training history
title_sort low-dimensional encoding of decisions in parietal cortex reflects long-term training history
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950136/
https://www.ncbi.nlm.nih.gov/pubmed/36823109
http://dx.doi.org/10.1038/s41467-023-36554-5
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