SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1

Ferroptosis is an iron-dependent cell death with the accumulation of lipid peroxidation and dysfunction of antioxidant systems. As the critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated to be down-regulated in amyotrophic lateral sclerosis (ALS). However, the mechanism of ferr...

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Detalles Bibliográficos
Autores principales: Wang, Di, Liang, Weiwei, Huo, Di, Wang, Hongyong, Wang, Ying, Cong, Chaohua, Zhang, Chunting, Yan, Shi, Gao, Ming, Su, Xiaoli, Tan, Xingli, Zhang, Wenmo, Han, Ling, Zhang, Dongmei, Feng, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950139/
https://www.ncbi.nlm.nih.gov/pubmed/36443440
http://dx.doi.org/10.1038/s41418-022-01089-7

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