Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro

Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate prodrug of an adenosine analog (GS-441524). Remdesivir is taken up by target cells and metabolized in multiple steps to form the active nucleoside triphosphate (GS-443902), which acts as a potent inhibitor of viral RNA-depend...

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Detalles Bibliográficos
Autores principales: Radoshitzky, Sheli R., Iversen, Patrick, Lu, Xianghan, Zou, Jing, Kaptein, Suzanne J. F., Stuthman, Kelly S., Van Tongeren, Sean A., Steffens, Jesse, Gong, Ruoyu, Truong, Hoa, Sapre, Annapurna A., Yang, Huiling, Xie, Xiaodong, Chia, Jia Jun, Song, Zhijuan J., Leventhal, Stacey M., Chan, Josolyn, Shornikov, Alex, Zhang, Xin, Cowfer, David, Yu, Helen, Warren, Travis, Cihlar, Tomas, Porter, Danielle P., Neyts, Johan, Shi, Pei-Yong, Wells, Jay, Bilello, John P., Feng, Joy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950143/
https://www.ncbi.nlm.nih.gov/pubmed/36823196
http://dx.doi.org/10.1038/s41598-023-29517-9

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