Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas

Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors exhibit significant heterogeneity, shaped by distinct genetic/epigenetic drivers, transcriptional programs including RNA...

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Detalles Bibliográficos
Autores principales: Ren, Yanming, Huang, Zongyao, Zhou, Lingling, Xiao, Peng, Song, Junwei, He, Ping, Xie, Chuanxing, Zhou, Ran, Li, Menghan, Dong, Xiangqun, Mao, Qing, You, Chao, Xu, Jianguo, Liu, Yanhui, Lan, Zhigang, Zhang, Tiejun, Gan, Qi, Yang, Yuan, Chen, Tengyun, Huang, Bowen, Yang, Xiang, Xiao, Anqi, Ou, Yun, Su, Zhengzheng, Chen, Lu, Zhang, Yan, Ju, Yan, Zhang, Yuekang, Wang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950149/
https://www.ncbi.nlm.nih.gov/pubmed/36823172
http://dx.doi.org/10.1038/s41467-023-36707-6

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