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CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

CLEC16A is a membrane-associated C-type lectin protein that functions as a E3-ubiquitin ligase. CLEC16A regulates autophagy and mitophagy, and reportedly localizes to late endosomes. GWAS studies have associated CLEC16A SNPs to various auto-immune and neurological disorders, including multiple scler...

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Detalles Bibliográficos
Autores principales:	Smits, Daphne J., Dekker, Jordy, Schot, Rachel, Tabarki, Brahim, Alhashem, Amal, Demmers, Jeroen A. A., Dekkers, Dick H. W., Romito, Antonio, van der Spek, Peter J., van Ham, Tjakko J., Bertoli-Avella, Aida M., Mancini, Grazia M. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950183/ https://www.ncbi.nlm.nih.gov/pubmed/36538041 http://dx.doi.org/10.1007/s00439-022-02511-3

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