Morpho-functional analysis of patient-derived xenografts reveals differential impact of gastric cancer and chemotherapy on the tumor ecosystem, affecting immune check point, metabolism, and sarcopenia

OBJECTIVES: Gastric cancer (GC) is an aggressive disease due to late diagnosis resulting from the lack of easy diagnostic tools, resistances toward immunotherapy (due to low PD-L1 expression), or chemotherapies (due to p53 mutations), and comorbidity factors, notably muscle atrophy. To improve our u...

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Detalles Bibliográficos
Autores principales: Venkatasamy, A., Guerin, E., Reichardt, W., Devignot, V., Chenard, M. P., Miguet, L., Romain, B., Jung, A. C., Gross, I., Gaiddon, C., Mellitzer, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950243/
https://www.ncbi.nlm.nih.gov/pubmed/36536236
http://dx.doi.org/10.1007/s10120-022-01359-w

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