Cargando…

LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer

BACKGROUND: LACTB was recently identified as a mitochondrial tumour suppressor that negatively affects cancer cell proliferation by inducing cell death and/or differentiation, depending on the cell type and tissue. However, the detailed mechanism underlying the LACTB-induced cancer cell death is lar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonzalez-Morena, Juan M., Escudeiro-Lopes, Sara, Ferreira-Mendes, Jessica Mariane, Jakoube, Pavel, Cutano, Valentina, Vinaixa-Forner, Judith, Kralova Viziova, Petra, Hartmanova, Andrea, Sedlacek, Radislav, Machado, Susana, Malcekova, Beata, Keckesova, Zuzana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950249/ https://www.ncbi.nlm.nih.gov/pubmed/36282364 http://dx.doi.org/10.1007/s10495-022-01775-4

Ejemplares similares

LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug
por: Cutano, Valentina, et al.
Publicado: (2022)

Mitochondrial Tumor Suppressors—The Energetic Enemies of Tumor Progression
por: Jakoube, Pavel, et al.
Publicado: (2021)

LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway
por: Xu, Yihui, et al.
Publicado: (2022)

LACTB, a Metabolic Therapeutic Target in Clinical Cancer Application
por: Li, Xiaohua, et al.
Publicado: (2022)

Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer
por: Yu, J, et al.
Publicado: (2016)

Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways
por: Minařík, Lubomír, et al.
Publicado: (2022)

Unveiling the Function of the Mitochondrial Filament-Forming Protein LACTB in Lipid Metabolism and Cancer
por: Cascone, Annunziata, et al.
Publicado: (2022)

MicroRNA-1276 Promotes Colon Cancer Cell Proliferation by Negatively Regulating LACTB
por: Wang, Chunxiao, et al.
Publicado: (2020)

Targeted Nanotherapeutics Using LACTB Gene Therapy Against Melanoma
por: Liu, Jinlu, et al.
Publicado: (2021)

The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding
por: Bennett, Jeremy A., et al.
Publicado: (2022)

Commentary: LACTB is a tumour suppressor that modulates lipid metabolism and cell state
por: Eriksson, Ove, et al.
Publicado: (2017)

Overexpression of LACTB, a Mitochondrial Protein That Inhibits Proliferation and Invasion in Glioma Cells
por: Li, Hai-Tao, et al.
Publicado: (2019)

LACTB and LC3 could serve as potential biomarkers of gastric cancer to neoadjuvant chemotherapy with oxaliplatin plus S-1
por: Yang, Fang, et al.
Publicado: (2021)

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease
por: Levy, Shiri, et al.
Publicado: (2016)

Upregulation of miR‐374a promotes tumor metastasis and progression by downregulating LACTB and predicts unfavorable prognosis in breast cancer
por: Zhang, Jun, et al.
Publicado: (2018)

LACTB mRNA expression is increased in pancreatic adenocarcinoma and high expression indicates a poor prognosis
por: Xie, Jian, et al.
Publicado: (2021)

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
por: Brentnall, Matthew, et al.
Publicado: (2013)

The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1β–mediated autoinflammatory osteomyelitis
por: Kralova, Jarmila, et al.
Publicado: (2021)

LACTB Regulates PIK3R3 to Promote Autophagy and Inhibit EMT and Proliferation Through the PI3K/AKT/mTOR Signaling Pathway in Colorectal Cancer
por: Xu, Wei, et al.
Publicado: (2020)

Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes
por: Crowley, Shauna M., et al.
Publicado: (2020)

Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation
por: Pavliuchenko, Nataliia, et al.
Publicado: (2022)

Shortcomings of short hairpin RNA-based transgenic RNA interference in mouse oocytes
por: Sarnova, Lenka, et al.
Publicado: (2010)

Gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting Akt and activating the intrinsic caspase cascade
por: Kim, Geun-Young, et al.
Publicado: (2015)

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
por: Boucher, Dave, et al.
Publicado: (2018)

Brazilin Isolated from Caesalpina Sappan Wood Induces Intrinsic Apoptosis on A549 Cancer Cell Line by Increasing p53, caspase-9, and caspase-3
por: Suyatmi, Suyatmi, et al.
Publicado: (2022)

CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review
por: Syding, Linn Amanda, et al.
Publicado: (2020)

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival
por: Pu, Xuan, et al.
Publicado: (2016)

Co-imaging extrinsic, intrinsic and effector caspase activity by fluorescence anisotropy microscopy
por: Corbat, Agustin A., et al.
Publicado: (2018)

Generation of mRx-Cre Transgenic Mouse Line for Efficient Conditional Gene Deletion in Early Retinal Progenitors
por: Klimova, Lucie, et al.
Publicado: (2013)

An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes
por: Chalupnikova, Katerina, et al.
Publicado: (2014)

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype
por: Kasparek, Petr, et al.
Publicado: (2017)

Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1
por: Fabisik, Matej, et al.
Publicado: (2021)

Loss of FADD and Caspases Affects the Response of T-Cell Leukemia Jurkat Cells to Anti-Cancer Drugs
por: Mrkvová, Zuzana, et al.
Publicado: (2021)

Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogen
por: Brauer, Rena, et al.
Publicado: (2011)

c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells
por: Kaspar, Petr, et al.
Publicado: (2019)

Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy
por: Martinez-Bosch, Neus, et al.
Publicado: (2018)

Chalcone-Induced Apoptosis through Caspase-Dependent Intrinsic Pathways in Human Hepatocellular Carcinoma Cells
por: Ramirez-Tagle, Rodrigo, et al.
Publicado: (2016)

Transcriptional profiling identifies caspase-1 as a T cell–intrinsic regulator of Th17 differentiation
por: Gao, Yajing, et al.
Publicado: (2020)

Secondary Metabolites of Saussurea costus Leaf Extract Induce Apoptosis in Breast, Liver, and Colon Cancer Cells by Caspase-3-Dependent Intrinsic Pathway
por: Shati, Ali A., et al.
Publicado: (2020)

OCT and ERG Techniques in High-Throughput Phenotyping of Mouse Vision
por: Lindovsky, Jiri, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u4a1qu4t3o3gs0kad0494mugsu