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A meta-analysis: Effect of androgens on reproduction in sows
INTRODUCTION: The mechanisms by which male hormones affect the development of ovaries and follicles has been studied by injecting exogenous androgens into sows. This may provide a reference for human polycystic ovary syndrome (PCOS), and can also provide guidance for improving the litter size of sow...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950266/ https://www.ncbi.nlm.nih.gov/pubmed/36843577 http://dx.doi.org/10.3389/fendo.2023.1094466 |
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author | Guo, Zhenhua Lv, Lei Liu, Di Ma, Hong Radovic, Cedomir |
author_facet | Guo, Zhenhua Lv, Lei Liu, Di Ma, Hong Radovic, Cedomir |
author_sort | Guo, Zhenhua |
collection | PubMed |
description | INTRODUCTION: The mechanisms by which male hormones affect the development of ovaries and follicles has been studied by injecting exogenous androgens into sows. This may provide a reference for human polycystic ovary syndrome (PCOS), and can also provide guidance for improving the litter size of sows. METHODS: We present a meta-analysis of studies published in the past 30 years on the effect of androgens on the ovulation rate of sows. A total of 517 papers were analyzed. RESULTS: The results showed that both testosterone (T) and dihydrotestosterone (DHT) injected into sows were positively related to the ovulation rate. T did not have a relevant effect on swine in vivo blastocyst survival rate. DHT had a negative phase with respect to blastocyst survival rate. Pig T-androgen receiver affinity was higher than the analogous affinity for DHT; this is different in humans. This suggests that sows are not suitable as human PCOS experimental animal models. DISCUSSION: To improve the litter size of sows, future research should focus on the mixed use of T and DHT, and the timing of use should be consistent with the periodic changes in androgen levels in sows. In addition, the welfare of experimental sows should be considered with reference to the clinical symptoms of PCOS. |
format | Online Article Text |
id | pubmed-9950266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99502662023-02-25 A meta-analysis: Effect of androgens on reproduction in sows Guo, Zhenhua Lv, Lei Liu, Di Ma, Hong Radovic, Cedomir Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: The mechanisms by which male hormones affect the development of ovaries and follicles has been studied by injecting exogenous androgens into sows. This may provide a reference for human polycystic ovary syndrome (PCOS), and can also provide guidance for improving the litter size of sows. METHODS: We present a meta-analysis of studies published in the past 30 years on the effect of androgens on the ovulation rate of sows. A total of 517 papers were analyzed. RESULTS: The results showed that both testosterone (T) and dihydrotestosterone (DHT) injected into sows were positively related to the ovulation rate. T did not have a relevant effect on swine in vivo blastocyst survival rate. DHT had a negative phase with respect to blastocyst survival rate. Pig T-androgen receiver affinity was higher than the analogous affinity for DHT; this is different in humans. This suggests that sows are not suitable as human PCOS experimental animal models. DISCUSSION: To improve the litter size of sows, future research should focus on the mixed use of T and DHT, and the timing of use should be consistent with the periodic changes in androgen levels in sows. In addition, the welfare of experimental sows should be considered with reference to the clinical symptoms of PCOS. Frontiers Media S.A. 2023-02-10 /pmc/articles/PMC9950266/ /pubmed/36843577 http://dx.doi.org/10.3389/fendo.2023.1094466 Text en Copyright © 2023 Guo, Lv, Liu, Ma and Radovic https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Guo, Zhenhua Lv, Lei Liu, Di Ma, Hong Radovic, Cedomir A meta-analysis: Effect of androgens on reproduction in sows |
title | A meta-analysis: Effect of androgens on reproduction in sows |
title_full | A meta-analysis: Effect of androgens on reproduction in sows |
title_fullStr | A meta-analysis: Effect of androgens on reproduction in sows |
title_full_unstemmed | A meta-analysis: Effect of androgens on reproduction in sows |
title_short | A meta-analysis: Effect of androgens on reproduction in sows |
title_sort | meta-analysis: effect of androgens on reproduction in sows |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950266/ https://www.ncbi.nlm.nih.gov/pubmed/36843577 http://dx.doi.org/10.3389/fendo.2023.1094466 |
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