A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis

Light chain (AL) amyloidosis is a debilitating disease in which mutant antibody light chains (LC), secreted by aberrant plasma cell clones, misfold and form insoluble fibrils, which can be deposited in various organs. In the majority of cases, the fibrillar deposits consist of LC variable domains (V...

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Detalles Bibliográficos
Autores principales: Rottenaicher, Georg J., Absmeier, Ramona M., Meier, Laura, Zacharias, Martin, Buchner, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950467/
https://www.ncbi.nlm.nih.gov/pubmed/36823438
http://dx.doi.org/10.1038/s42003-023-04574-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950467/
https://www.ncbi.nlm.nih.gov/pubmed/36823438
http://dx.doi.org/10.1038/s42003-023-04574-y

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