Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation

Oncogenic KRAS is the key driver oncogene for several of the most aggressive human cancers. One key feature of oncogenic KRAS expression is an early increase in cellular reactive oxygen species (ROS) which promotes cellular transformation if cells manage to escape cell death, mechanisms of which rem...

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Detalles Bibliográficos
Autores principales: Müller, Fabienne, Lim, Jonathan K. M., Bebber, Christina M., Seidel, Eric, Tishina, Sofya, Dahlhaus, Alina, Stroh, Jenny, Beck, Julia, Yapici, Fatma Isil, Nakayama, Keiko, Torres Fernández, Lucia, Brägelmann, Johannes, Leprivier, Gabriel, von Karstedt, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950476/
https://www.ncbi.nlm.nih.gov/pubmed/36443441
http://dx.doi.org/10.1038/s41418-022-01096-8

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