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Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma
We determined the effect of exercise‐induced bronchoconstriction (EIB) on the shape of the maximal expiratory flow‐volume (MEFV) curve in asthmatic adults. The slope‐ratio index (SR) was used to quantitate the shape of the MEFV curve. We hypothesized that EIB would be accompanied by increases in SR...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950550/ https://www.ncbi.nlm.nih.gov/pubmed/36823958 http://dx.doi.org/10.14814/phy2.15614 |
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author | Klimenko, Oksana Luu, Peter Dominelli, Paolo Noggle, Nathan Petrics, Gregory Haverkamp, Hans Christian |
author_facet | Klimenko, Oksana Luu, Peter Dominelli, Paolo Noggle, Nathan Petrics, Gregory Haverkamp, Hans Christian |
author_sort | Klimenko, Oksana |
collection | PubMed |
description | We determined the effect of exercise‐induced bronchoconstriction (EIB) on the shape of the maximal expiratory flow‐volume (MEFV) curve in asthmatic adults. The slope‐ratio index (SR) was used to quantitate the shape of the MEFV curve. We hypothesized that EIB would be accompanied by increases in SR and thus increased curvilinearity of the MEFV curve. Adult asthmatic ( n = 10) and non‐asthmatic control subjects ( n = 9) cycled for 6–8 min at 85% of peak power. Following exercise, subjects remained on the ergometer and performed a maximal forced exhalation every 2 min for a total 20 min. In each MEFV curve, the slope‐ratio index (SR) was calculated in 1% volume increments beginning at peak expiratory flow (PEF) and ending at 20% of forced vital capacity (FVC). Baseline spirometry was lower in asthmatics compared to control subjects (FEV(1)% predicted, 89.1 ± 14.3 vs. 96.5 ± 12.2% [SD] in asthma vs. control; p < 0.05). In asthmatic subjects, post‐exercise FEV(1) decreased by 29.9 ± 13.2% from baseline (3.48 ± 0.74 and 2.24 ± 0.59 [SD] L for baseline and post‐exercise nadir; p < 0.001). At baseline and at all timepoints after exercise, average SR between 80 and 20% of FVC was larger in asthmatic than control subjects (1.48 ± 0.02 vs. 1.23 ± 0.02 [SD] for asthma vs. control; p < 0.005). This averaged SR did not change after exercise in either subject group. In contrast, post‐exercise SR between PEF and 75% of FVC was increased from baseline in subjects with asthma, suggesting that airway caliber heterogeneity increases with EIB. These findings suggest that the SR‐index might provide useful information on the physiology of acute airway narrowing that complements traditional spirometric measures. |
format | Online Article Text |
id | pubmed-9950550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99505502023-02-25 Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma Klimenko, Oksana Luu, Peter Dominelli, Paolo Noggle, Nathan Petrics, Gregory Haverkamp, Hans Christian Physiol Rep Original Articles We determined the effect of exercise‐induced bronchoconstriction (EIB) on the shape of the maximal expiratory flow‐volume (MEFV) curve in asthmatic adults. The slope‐ratio index (SR) was used to quantitate the shape of the MEFV curve. We hypothesized that EIB would be accompanied by increases in SR and thus increased curvilinearity of the MEFV curve. Adult asthmatic ( n = 10) and non‐asthmatic control subjects ( n = 9) cycled for 6–8 min at 85% of peak power. Following exercise, subjects remained on the ergometer and performed a maximal forced exhalation every 2 min for a total 20 min. In each MEFV curve, the slope‐ratio index (SR) was calculated in 1% volume increments beginning at peak expiratory flow (PEF) and ending at 20% of forced vital capacity (FVC). Baseline spirometry was lower in asthmatics compared to control subjects (FEV(1)% predicted, 89.1 ± 14.3 vs. 96.5 ± 12.2% [SD] in asthma vs. control; p < 0.05). In asthmatic subjects, post‐exercise FEV(1) decreased by 29.9 ± 13.2% from baseline (3.48 ± 0.74 and 2.24 ± 0.59 [SD] L for baseline and post‐exercise nadir; p < 0.001). At baseline and at all timepoints after exercise, average SR between 80 and 20% of FVC was larger in asthmatic than control subjects (1.48 ± 0.02 vs. 1.23 ± 0.02 [SD] for asthma vs. control; p < 0.005). This averaged SR did not change after exercise in either subject group. In contrast, post‐exercise SR between PEF and 75% of FVC was increased from baseline in subjects with asthma, suggesting that airway caliber heterogeneity increases with EIB. These findings suggest that the SR‐index might provide useful information on the physiology of acute airway narrowing that complements traditional spirometric measures. John Wiley and Sons Inc. 2023-02-23 /pmc/articles/PMC9950550/ /pubmed/36823958 http://dx.doi.org/10.14814/phy2.15614 Text en © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Klimenko, Oksana Luu, Peter Dominelli, Paolo Noggle, Nathan Petrics, Gregory Haverkamp, Hans Christian Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma |
title | Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma |
title_full | Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma |
title_fullStr | Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma |
title_full_unstemmed | Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma |
title_short | Effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma |
title_sort | effect of exercise‐induced bronchoconstriction on the configuration of the maximal expiratory flow‐volume curve in adults with asthma |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950550/ https://www.ncbi.nlm.nih.gov/pubmed/36823958 http://dx.doi.org/10.14814/phy2.15614 |
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