Endoglin in head and neck neoplasms

Tumors of the head and neck region form a heterogeneous group of pathologies, including various benign lesions and malignant neoplasms. Endoglin, also known as CD105, is an accessory receptor for transforming growth factor beta (TGF-β), that regulates angiogenesis, both under physiological and patho...

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Autores principales: Litwiniuk-Kosmala, Małgorzata, Makuszewska, Maria, Czesak, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950573/
https://www.ncbi.nlm.nih.gov/pubmed/36844233
http://dx.doi.org/10.3389/fmed.2023.1115212
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author Litwiniuk-Kosmala, Małgorzata
Makuszewska, Maria
Czesak, Małgorzata
author_facet Litwiniuk-Kosmala, Małgorzata
Makuszewska, Maria
Czesak, Małgorzata
author_sort Litwiniuk-Kosmala, Małgorzata
collection PubMed
description Tumors of the head and neck region form a heterogeneous group of pathologies, including various benign lesions and malignant neoplasms. Endoglin, also known as CD105, is an accessory receptor for transforming growth factor beta (TGF-β), that regulates angiogenesis, both under physiological and pathological conditions. It is highly expressed in proliferating endothelial cells. Therefore, it is considered as a marker of tumor-related angiogenesis. In this review we discuss the role of endoglin as a possible marker of carcinogenesis, as well as a potential target for antibody-based therapies in the neoplasms of the head and neck region.
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spelling pubmed-99505732023-02-25 Endoglin in head and neck neoplasms Litwiniuk-Kosmala, Małgorzata Makuszewska, Maria Czesak, Małgorzata Front Med (Lausanne) Medicine Tumors of the head and neck region form a heterogeneous group of pathologies, including various benign lesions and malignant neoplasms. Endoglin, also known as CD105, is an accessory receptor for transforming growth factor beta (TGF-β), that regulates angiogenesis, both under physiological and pathological conditions. It is highly expressed in proliferating endothelial cells. Therefore, it is considered as a marker of tumor-related angiogenesis. In this review we discuss the role of endoglin as a possible marker of carcinogenesis, as well as a potential target for antibody-based therapies in the neoplasms of the head and neck region. Frontiers Media S.A. 2023-02-10 /pmc/articles/PMC9950573/ /pubmed/36844233 http://dx.doi.org/10.3389/fmed.2023.1115212 Text en Copyright © 2023 Litwiniuk-Kosmala, Makuszewska and Czesak. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Litwiniuk-Kosmala, Małgorzata
Makuszewska, Maria
Czesak, Małgorzata
Endoglin in head and neck neoplasms
title Endoglin in head and neck neoplasms
title_full Endoglin in head and neck neoplasms
title_fullStr Endoglin in head and neck neoplasms
title_full_unstemmed Endoglin in head and neck neoplasms
title_short Endoglin in head and neck neoplasms
title_sort endoglin in head and neck neoplasms
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950573/
https://www.ncbi.nlm.nih.gov/pubmed/36844233
http://dx.doi.org/10.3389/fmed.2023.1115212
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