Clinical antidiabetic medication used in Alzheimer’s disease: From basic discovery to therapeutics development

Alzheimer’s disease (AD) is a common neurodegenerative disease. Type 2 diabetes mellitus (T2DM) appears to increase and contributing to the risk of AD. Therefore, there is increasing concern about clinical antidiabetic medication used in AD. Most of them show some potential in basic research, but no...

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Autores principales: Huang, Juan, Huang, Nanqu, Cui, Di, Shi, Jingshan, Qiu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950577/
https://www.ncbi.nlm.nih.gov/pubmed/36845652
http://dx.doi.org/10.3389/fnagi.2023.1122300
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author Huang, Juan
Huang, Nanqu
Cui, Di
Shi, Jingshan
Qiu, Yu
author_facet Huang, Juan
Huang, Nanqu
Cui, Di
Shi, Jingshan
Qiu, Yu
author_sort Huang, Juan
collection PubMed
description Alzheimer’s disease (AD) is a common neurodegenerative disease. Type 2 diabetes mellitus (T2DM) appears to increase and contributing to the risk of AD. Therefore, there is increasing concern about clinical antidiabetic medication used in AD. Most of them show some potential in basic research, but not in clinical research. So we reviewed the opportunities and challenges faced by some antidiabetic medication used in AD from basic to clinical research. Based on existing research progress, this is still the hope of some patients with special types of AD caused by rising blood glucose or/and insulin resistance.
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spelling pubmed-99505772023-02-25 Clinical antidiabetic medication used in Alzheimer’s disease: From basic discovery to therapeutics development Huang, Juan Huang, Nanqu Cui, Di Shi, Jingshan Qiu, Yu Front Aging Neurosci Neuroscience Alzheimer’s disease (AD) is a common neurodegenerative disease. Type 2 diabetes mellitus (T2DM) appears to increase and contributing to the risk of AD. Therefore, there is increasing concern about clinical antidiabetic medication used in AD. Most of them show some potential in basic research, but not in clinical research. So we reviewed the opportunities and challenges faced by some antidiabetic medication used in AD from basic to clinical research. Based on existing research progress, this is still the hope of some patients with special types of AD caused by rising blood glucose or/and insulin resistance. Frontiers Media S.A. 2023-02-10 /pmc/articles/PMC9950577/ /pubmed/36845652 http://dx.doi.org/10.3389/fnagi.2023.1122300 Text en Copyright © 2023 Huang, Huang, Cui, Shi and Qiu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Huang, Juan
Huang, Nanqu
Cui, Di
Shi, Jingshan
Qiu, Yu
Clinical antidiabetic medication used in Alzheimer’s disease: From basic discovery to therapeutics development
title Clinical antidiabetic medication used in Alzheimer’s disease: From basic discovery to therapeutics development
title_full Clinical antidiabetic medication used in Alzheimer’s disease: From basic discovery to therapeutics development
title_fullStr Clinical antidiabetic medication used in Alzheimer’s disease: From basic discovery to therapeutics development
title_full_unstemmed Clinical antidiabetic medication used in Alzheimer’s disease: From basic discovery to therapeutics development
title_short Clinical antidiabetic medication used in Alzheimer’s disease: From basic discovery to therapeutics development
title_sort clinical antidiabetic medication used in alzheimer’s disease: from basic discovery to therapeutics development
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950577/
https://www.ncbi.nlm.nih.gov/pubmed/36845652
http://dx.doi.org/10.3389/fnagi.2023.1122300
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