GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation

Supraphysiological concentrations of oxygen (hyperoxia) can compromise host defense and increase susceptibility to bacterial and viral infections, causing ventilator-associated pneumonia (VAP). Compromised host defense and inflammatory lung injury are mediated, in part, by high extracellular concent...

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Detalles Bibliográficos
Autores principales: Gauthier, Alex G., Lin, Mosi, Zefi, Sidorela, Kulkarni, Abhijit, Thakur, Ganesh A., Ashby, Charles R., Mantell, Lin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles from the Special Issue on Redox signaling in the pathogenesis and treatments of acute lung injury and beyond, Edited by: Dr. Lin Mantell, Dr. Peter Vitiello and Dr. Eva Nozik
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950665/
https://www.ncbi.nlm.nih.gov/pubmed/36717349
http://dx.doi.org/10.1016/j.redox.2023.102614

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