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Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma
Differentiated thyroid carcinomas tend to remain localized and usually are of slow progression with excellent long-term survival. The major sites of distant metastases are cervical lymph nodes, lungs and bones and the minor sites include the brain, liver, pericardium, skin, kidney, pleura and muscle...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950734/ https://www.ncbi.nlm.nih.gov/pubmed/36845746 http://dx.doi.org/10.3389/fonc.2023.994729 |
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author | Stergioula, Anastasia Pantelis, Evaggelos Kormas, Theodoros Agrogiannis, Georgios |
author_facet | Stergioula, Anastasia Pantelis, Evaggelos Kormas, Theodoros Agrogiannis, Georgios |
author_sort | Stergioula, Anastasia |
collection | PubMed |
description | Differentiated thyroid carcinomas tend to remain localized and usually are of slow progression with excellent long-term survival. The major sites of distant metastases are cervical lymph nodes, lungs and bones and the minor sites include the brain, liver, pericardium, skin, kidney, pleura and muscle. Skeletal muscle metastases from differentiated thyroid carcinoma, are exceedingly rare. In this report, a 42-year-old woman with follicular thyroid cancer that had had a total thyroidectomy and radioiodine ablation nine years ago was presented with a painful right thigh mass and negative PET/CT scan. The patient had also lung metastases during the follow-up period which were treated with surgery, chemotherapy and radiation therapy. An MRI scan of the right thigh showed a deep-seated lobulated mass with cystic regions, bleeding elements and strong heterogeneous post contrast administration enhancement. Due to the similarities in clinical manifestations and imaging features between soft tissue tumors and skeletal muscle metastases, the case was initially misdiagnosed in favor of synovial sarcoma. Histopathological, immunohistochemistry and molecular analysis of the soft tissue mass confirmed to be a thyroid metastasis and, as a result, a final diagnosis of skeletal muscle metastasis was provided. Even though the probability of a skeletal muscle metastasis from thyroid cancer approaches zero, this study aims to raise the awareness to the medical community that these events do in fact occur in the clinical setting and should be considered in the differential diagnosis of patients with thyroid carcinomas. |
format | Online Article Text |
id | pubmed-9950734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99507342023-02-25 Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma Stergioula, Anastasia Pantelis, Evaggelos Kormas, Theodoros Agrogiannis, Georgios Front Oncol Oncology Differentiated thyroid carcinomas tend to remain localized and usually are of slow progression with excellent long-term survival. The major sites of distant metastases are cervical lymph nodes, lungs and bones and the minor sites include the brain, liver, pericardium, skin, kidney, pleura and muscle. Skeletal muscle metastases from differentiated thyroid carcinoma, are exceedingly rare. In this report, a 42-year-old woman with follicular thyroid cancer that had had a total thyroidectomy and radioiodine ablation nine years ago was presented with a painful right thigh mass and negative PET/CT scan. The patient had also lung metastases during the follow-up period which were treated with surgery, chemotherapy and radiation therapy. An MRI scan of the right thigh showed a deep-seated lobulated mass with cystic regions, bleeding elements and strong heterogeneous post contrast administration enhancement. Due to the similarities in clinical manifestations and imaging features between soft tissue tumors and skeletal muscle metastases, the case was initially misdiagnosed in favor of synovial sarcoma. Histopathological, immunohistochemistry and molecular analysis of the soft tissue mass confirmed to be a thyroid metastasis and, as a result, a final diagnosis of skeletal muscle metastasis was provided. Even though the probability of a skeletal muscle metastasis from thyroid cancer approaches zero, this study aims to raise the awareness to the medical community that these events do in fact occur in the clinical setting and should be considered in the differential diagnosis of patients with thyroid carcinomas. Frontiers Media S.A. 2023-02-10 /pmc/articles/PMC9950734/ /pubmed/36845746 http://dx.doi.org/10.3389/fonc.2023.994729 Text en Copyright © 2023 Stergioula, Pantelis, Kormas and Agrogiannis https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Stergioula, Anastasia Pantelis, Evaggelos Kormas, Theodoros Agrogiannis, Georgios Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma |
title | Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma |
title_full | Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma |
title_fullStr | Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma |
title_full_unstemmed | Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma |
title_short | Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma |
title_sort | case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950734/ https://www.ncbi.nlm.nih.gov/pubmed/36845746 http://dx.doi.org/10.3389/fonc.2023.994729 |
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