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Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy

BACKGROUND: Adoptive transfer of patient’s T cells, engineered to express a T cell receptor (TCR) with defined novel antigen specificity, is a convenient form of cancer therapy. In most cases, major histocompatibility complex (MHC) I-restricted TCRs are expressed in CD8(+) T cells and the developmen...

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Detalles Bibliográficos
Autores principales:	Plewa, Natalia, Poncette, Lucia, Blankenstein, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950979/ https://www.ncbi.nlm.nih.gov/pubmed/36822673 http://dx.doi.org/10.1136/jitc-2022-006001

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